ID   Y2095_RHIME             Reviewed;        1029 AA.
AC   Q52999;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Uncharacterized protein R02095;
GN   OrderedLocusNames=R02095; ORFNames=SMc01491;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-483.
RC   STRAIN=1021;
RA   Bent A.F., Signer E.R.;
RL   Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA88525.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AL591688; CAC46674.1; -; Genomic_DNA.
DR   EMBL; M30934; AAA88525.1; ALT_FRAME; Genomic_DNA.
DR   RefSeq; NP_386201.1; NC_003047.1.
DR   AlphaFoldDB; Q52999; -.
DR   SMR; Q52999; -.
DR   STRING; 266834.SMc01491; -.
DR   EnsemblBacteria; CAC46674; CAC46674; SMc01491.
DR   KEGG; sme:SMc01491; -.
DR   PATRIC; fig|266834.11.peg.3551; -.
DR   eggNOG; COG1672; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_004435_3_1_5; -.
DR   OMA; YWGWWFT; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..1029
FT                   /note="Uncharacterized protein R02095"
FT                   /id="PRO_0000074134"
FT   DOMAIN          39..168
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         261..268
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        323
FT                   /note="A -> P (in Ref. 3)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1029 AA;  112710 MW;  4EA478188B601958 CRC64;
     MREWCMLRES RTNTPRRAAE RGKRPGGSSV RGGERRIVTA LCYDLVGSTD LMHVMDIEDY
     QELMSAFQLA SKQAIASHSG VMQHEAGDGG VALFPIELEA KDAASLAIRA GLGIVEACKR
     VGREAGQDDL QVRVGIATSV ALVLEGSREG WTREPVTGAA LAMAARLQAI TAPNSVLVSE
     ETRHLAGRSY AFVFQGSKEL KGFAAPEKVW RALGHKVGVD RFYAFGRMGG PLINRENELN
     TIGQLWDGVL AGQGSVVLIQ GDAGIGKSRL LREIRRRTRA KRSKLLFFQC LPGGFRSTLH
     PLLNNLPEAV SGSAGQMGPT AAAVAALFER NGIRDPAVVD VFSYLLGAQG SRLQSNEDPK
     AIREKAHRAL LRALEAVCRR GPAVVAVEDV HWIDPTSRDL LGEAARIIAK FPVLLVTTSR
     PSYASEWLDA ANPTRLALRP LDSDETRLAI KAKWPEHRLA LLPDLFDATE RISGGVPLFI
     EEICQWVSQN VEPDTMRLSE SANPSHVSAF ESILESRLQQ LGTAREVARA AAVAGTQVTL
     PLLRALLPDF GKSALANAAD TLCETGFLTR IRVPGRTAYG FRHTLIQETI YNAVLRKQRQ
     VLHRRLFTAV NQNRGMAAWI DTGALAEHAE RAGLVEEAVP LFIAAGKESS SRSAMIEARQ
     FLEHALDLCG QMSESDTAEA LKLLALTALG PILIGTVGLS SEPARRLYED AVEIARRRPM
     SEQSQWFPIY WGWWLTGQDF RVMHDRALEV RSMLSKANEP EIQLQVNHCI WAIDFNLGRH
     RETQDAIKAG LALYDEKRAK ESRTEFGGHD AKVCGLGQLA LSLWLTGRTK ASDAALSRMI
     AFTDRIAHAH SKAHSLDTEA VSAFYRDDFE RLTEVSARMA DFAKRHKMQS LSGQSLLFSG
     WAEAHRTGLA SGHARFQNGL SLLRELGAVA DLPIYLCMHA TLLGLAGKIE PAIEVVNEAI
     GRGEETGHAY WLAELHRCRA ILRARAGERK DAVAADLRCA VEIAESQGAT ALTRRARHSM
     RELGIVIGR