ID   Y2103_STAA8             Reviewed;         328 AA.
AC   Q2FX03;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=UPF0421 protein SAOUHSC_02103;
GN   OrderedLocusNames=SAOUHSC_02103;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   MUTANT STUDIES.
RX   PubMed=16923874; DOI=10.1128/jb.00551-06;
RA   Shaw L.N., Aish J., Davenport J.E., Brown M.C., Lithgow J.K., Simmonite K.,
RA   Crossley H., Travis J., Potempa J., Foster S.J.;
RT   "Investigations into sigmaB-modulated regulatory pathways governing
RT   extracellular virulence determinant production in Staphylococcus aureus.";
RL   J. Bacteriol. 188:6070-6080(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Disruption of this gene leads to an increase in hla
CC       (alpha-hemolysin) transcription and proteases production.
CC   -!- SIMILARITY: Belongs to the UPF0421 family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31153.1; -; Genomic_DNA.
DR   RefSeq; WP_000999713.1; NZ_LS483365.1.
DR   RefSeq; YP_500595.1; NC_007795.1.
DR   AlphaFoldDB; Q2FX03; -.
DR   SMR; Q2FX03; -.
DR   STRING; 1280.SAXN108_1987; -.
DR   EnsemblBacteria; ABD31153; ABD31153; SAOUHSC_02103.
DR   GeneID; 3921175; -.
DR   KEGG; sao:SAOUHSC_02103; -.
DR   PATRIC; fig|93061.5.peg.1908; -.
DR   eggNOG; COG4129; Bacteria.
DR   HOGENOM; CLU_067028_0_0_9; -.
DR   OMA; ANVMEEW; -.
DR   PRO; PR:Q2FX03; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR010343; ArAE_1.
DR   Pfam; PF06081; ArAE_1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="UPF0421 protein SAOUHSC_02103"
FT                   /id="PRO_0000283014"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  37436 MW;  3AA90C796DF97494 CRC64;
     MNDQWYKHLI GARTIKTGIA IFLTAVFCMA LDLTPIYAIL TAVVTIEPTA KASLIKGYRR
     LPATVIGAGF AVLFTYLFGD QSPFTYALSA TFTILFCTKL KLQVGTNVAV LTSLAMIPGI
     HDAYIFNFLS RTLTAIIGLV TSGLINFMVF PPKYYGQVEE KLSKTDALMY KLFYNRCQEL
     ILSRLQSDKS EKAYKNIFNL NNQVETLISY QRDELSYHKK KECDWKLLNQ LTKRAYTNRL
     FITHLSNIIY LPKNTRVNFS GDEKMALLKI SSSIKDIFYD GSFKREDDSV ETLRSTIKAL
     EISGENQIKS HILYEVLMIY RLLDSRYA