ID   CAR17_HUMAN             Reviewed;         110 AA.
AC   Q5XLA6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Caspase recruitment domain-containing protein 17;
DE   AltName: Full=Caspase-1 inhibitor INCA;
DE   AltName: Full=Inhibitory caspase recruitment domain protein;
GN   Name=CARD17; Synonyms=INCA;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CASP1, INDUCTION,
RP   AND TISSUE SPECIFICITY.
RX   PubMed=15383541; DOI=10.1074/jbc.m407891200;
RA   Lamkanfi M., Denecker G., Kalai M., D'hondt K., Meeus A., Declercq W.,
RA   Saelens X., Vandenabeele P.;
RT   "INCA, a novel human caspase recruitment domain protein that inhibits
RT   interleukin-1beta generation.";
RL   J. Biol. Chem. 279:51729-51738(2004).
CC   -!- FUNCTION: Regulator of procaspase-1/CASP1 activation implicated in the
CC       regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its
CC       release during inflammation. Inhibits the release of IL1B in response
CC       to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B
CC       activation. {ECO:0000269|PubMed:15383541}.
CC   -!- SUBUNIT: Interacts with pro-CASP1. {ECO:0000269|PubMed:15383541}.
CC   -!- INTERACTION:
CC       Q5XLA6; P29466: CASP1; NbExp=3; IntAct=EBI-16203934, EBI-516667;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:15383541}.
CC   -!- INDUCTION: By IFNG/IFN-gamma in monocytic cell lines.
CC       {ECO:0000269|PubMed:15383541}.
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DR   EMBL; AY761064; AAV28630.1; -; mRNA.
DR   RefSeq; NP_001007233.1; NM_001007232.1.
DR   AlphaFoldDB; Q5XLA6; -.
DR   SMR; Q5XLA6; -.
DR   BioGRID; 136265; 1.
DR   DIP; DIP-61990N; -.
DR   IntAct; Q5XLA6; 1.
DR   STRING; 9606.ENSP00000364859; -.
DR   iPTMnet; Q5XLA6; -.
DR   PhosphoSitePlus; Q5XLA6; -.
DR   BioMuta; CARD17; -.
DR   DMDM; 74724394; -.
DR   EPD; Q5XLA6; -.
DR   jPOST; Q5XLA6; -.
DR   MassIVE; Q5XLA6; -.
DR   PaxDb; Q5XLA6; -.
DR   PeptideAtlas; Q5XLA6; -.
DR   PRIDE; Q5XLA6; -.
DR   ProteomicsDB; 65837; -.
DR   DNASU; 440068; -.
DR   GeneID; 440068; -.
DR   UCSC; uc001pir.1; human.
DR   CTD; 440068; -.
DR   DisGeNET; 440068; -.
DR   GeneCards; CARD17; -.
DR   HGNC; HGNC:33827; CARD17.
DR   MIM; 609490; gene.
DR   neXtProt; NX_Q5XLA6; -.
DR   PharmGKB; PA164717641; -.
DR   VEuPathDB; HostDB:ENSG00000255221; -.
DR   eggNOG; KOG3573; Eukaryota.
DR   HOGENOM; CLU_119795_1_0_1; -.
DR   InParanoid; Q5XLA6; -.
DR   OMA; RDPGVYN; -.
DR   PhylomeDB; Q5XLA6; -.
DR   TreeFam; TF330675; -.
DR   PathwayCommons; Q5XLA6; -.
DR   SignaLink; Q5XLA6; -.
DR   BioGRID-ORCS; 440068; 12 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 440068; -.
DR   Pharos; Q5XLA6; Tbio.
DR   PRO; PR:Q5XLA6; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q5XLA6; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0089720; F:caspase binding; IPI:UniProtKB.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:UniProtKB.
DR   GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IDA:UniProtKB.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   Pfam; PF00619; CARD; 1.
DR   SMART; SM00114; CARD; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   PROSITE; PS50209; CARD; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Protease inhibitor; Reference proteome;
KW   Thiol protease inhibitor.
FT   CHAIN           1..110
FT                   /note="Caspase recruitment domain-containing protein 17"
FT                   /id="PRO_0000344504"
FT   DOMAIN          1..91
FT                   /note="CARD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
SQ   SEQUENCE   110 AA;  11868 MW;  84B5BAE7345E32B3 CRC64;
     MADKVLKEKR KQFIRSVGEG TINGLLGELL ETRVLSQEEI EIVKCENATV MDKARALLDS
     VIRKGAPACQ ICITYICEED SHLAGTLGLS AGPTSGNHLT TQDSQIVLPS