ID   Y2107_DICDI             Reviewed;         147 AA.
AC   Q54SZ9;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282107;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0282107;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000045; EAL66379.1; -; Genomic_DNA.
DR   RefSeq; XP_640356.1; XM_635264.1.
DR   AlphaFoldDB; Q54SZ9; -.
DR   SMR; Q54SZ9; -.
DR   STRING; 44689.DDB0230194; -.
DR   PaxDb; Q54SZ9; -.
DR   EnsemblProtists; EAL66379; EAL66379; DDB_G0282107.
DR   GeneID; 8623411; -.
DR   KEGG; ddi:DDB_G0282107; -.
DR   dictyBase; DDB_G0282107; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_097982_2_0_1; -.
DR   InParanoid; Q54SZ9; -.
DR   OMA; QTYDLCE; -.
DR   PhylomeDB; Q54SZ9; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8964038; LDL clearance.
DR   PRO; PR:Q54SZ9; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   Gene3D; 2.70.220.10; -; 1.
DR   InterPro; IPR036846; GM2-AP_sf.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..147
FT                   /note="Putative phosphatidylglycerol/phosphatidylinositol
FT                   transfer protein DDB_G0282107"
FT                   /id="PRO_0000389013"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   147 AA;  16148 MW;  428D0B19E5F14EC0 CRC64;
     MKQKLLLFIF SILILLIAAE AKMFKDIWKS CGKSTDTFQI KNVTISPDPP VRGQTVSIYA
     SGELKDTISG GDVNIQIKFG IITIIRETKP ICSSDNPFPC PIQPGDYTHS VDIAIPDNAP
     RGKYSGNFVL TDQANDEIAC INVNMQL