ID   CAR19_BOVIN             Reviewed;         183 AA.
AC   Q58D91;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Caspase recruitment domain-containing protein 19;
DE   AltName: Full=Bcl10-interacting CARD protein;
DE            Short=BinCARD;
GN   Name=CARD19;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Plays a role in inhibiting the effects of BCL10-induced
CC       activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a
CC       CARD-dependent manner. {ECO:0000250|UniProtKB:Q96LW7}.
CC   -!- SUBUNIT: Associates with BCL10 by CARD-CARD interaction.
CC       {ECO:0000250|UniProtKB:Q96LW7}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane
CC       {ECO:0000250}; Single-pass membrane protein.
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DR   EMBL; BT021706; AAX46553.1; -; mRNA.
DR   RefSeq; NP_001029925.1; NM_001034753.1.
DR   AlphaFoldDB; Q58D91; -.
DR   SMR; Q58D91; -.
DR   STRING; 9913.ENSBTAP00000014878; -.
DR   PaxDb; Q58D91; -.
DR   GeneID; 614217; -.
DR   KEGG; bta:614217; -.
DR   CTD; 84270; -.
DR   eggNOG; ENOG502RYMQ; Eukaryota.
DR   OrthoDB; 1251938at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   CDD; cd13785; CARD_BinCARD_like; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   InterPro; IPR043574; CARD19.
DR   InterPro; IPR042146; CARD_BinCARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   PANTHER; PTHR34765; PTHR34765; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Endoplasmic reticulum; Membrane; Mitochondrion;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..183
FT                   /note="Caspase recruitment domain-containing protein 19"
FT                   /id="PRO_0000064926"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          8..99
FT                   /note="CARD"
FT   DISULFID        7..77
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  20560 MW;  A3D1C3FF580C7714 CRC64;
     MTEQTYCDRL VQDTPFLTSL GRLSEQQVDR IILQLNRYYP QILSNKDAEK FRNPKLSLRV
     RLCDLLGHLQ RSGERDCQEF YRALYIHAQP LHSCLPSRHA LQNSDCTELD SGNASCELSD
     RGPVAFLTCL GLAAGLALLI YCCPPDPKVL PGARRVLGFS PVIIDRHVSR FLLAFLTDDL
     GGL