CAR19_MOUSE
ID CAR19_MOUSE Reviewed; 183 AA.
AC Q9D1I2; Q3U3Y9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Caspase recruitment domain-containing protein 19 {ECO:0000312|MGI:MGI:1915730};
DE AltName: Full=Bcl10-interacting CARD protein {ECO:0000250|UniProtKB:Q96LW7};
DE Short=BinCARD {ECO:0000250|UniProtKB:Q96LW7};
GN Name=Card19 {ECO:0000312|MGI:MGI:1915730};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in inhibiting the effects of BCL10-induced
CC activation of NF-kappa-B. {ECO:0000250|UniProtKB:Q96LW7}.
CC -!- SUBUNIT: Associates with BCL10 by CARD-CARD interaction.
CC {ECO:0000250|UniProtKB:Q96LW7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane
CC {ECO:0000250}; Single-pass membrane protein.
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DR EMBL; AK003526; BAB22838.1; -; mRNA.
DR EMBL; AK154517; BAE32646.1; -; mRNA.
DR CCDS; CCDS49260.1; -.
DR RefSeq; NP_081014.1; NM_026738.2.
DR AlphaFoldDB; Q9D1I2; -.
DR SMR; Q9D1I2; -.
DR STRING; 10090.ENSMUSP00000047569; -.
DR PhosphoSitePlus; Q9D1I2; -.
DR EPD; Q9D1I2; -.
DR MaxQB; Q9D1I2; -.
DR PaxDb; Q9D1I2; -.
DR PRIDE; Q9D1I2; -.
DR ProteomicsDB; 265334; -.
DR Antibodypedia; 28349; 146 antibodies from 20 providers.
DR Ensembl; ENSMUST00000048946; ENSMUSP00000047569; ENSMUSG00000037960.
DR GeneID; 68480; -.
DR KEGG; mmu:68480; -.
DR UCSC; uc007qiy.1; mouse.
DR CTD; 84270; -.
DR MGI; MGI:1915730; Card19.
DR VEuPathDB; HostDB:ENSMUSG00000037960; -.
DR eggNOG; ENOG502RYMQ; Eukaryota.
DR GeneTree; ENSGT00390000016408; -.
DR HOGENOM; CLU_103797_0_0_1; -.
DR InParanoid; Q9D1I2; -.
DR OMA; TLQNSDC; -.
DR OrthoDB; 1251938at2759; -.
DR PhylomeDB; Q9D1I2; -.
DR TreeFam; TF335747; -.
DR BioGRID-ORCS; 68480; 2 hits in 40 CRISPR screens.
DR ChiTaRS; Card19; mouse.
DR PRO; PR:Q9D1I2; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9D1I2; protein.
DR Bgee; ENSMUSG00000037960; Expressed in granulocyte and 196 other tissues.
DR ExpressionAtlas; Q9D1I2; baseline and differential.
DR Genevisible; Q9D1I2; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd13785; CARD_BinCARD_like; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR043574; CARD19.
DR InterPro; IPR042146; CARD_BinCARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR PANTHER; PTHR34765; PTHR34765; 1.
DR Pfam; PF00619; CARD; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Endoplasmic reticulum; Membrane; Mitochondrion;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..183
FT /note="Caspase recruitment domain-containing protein 19"
FT /id="PRO_0000064928"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 8..99
FT /note="CARD"
FT DISULFID 7..77
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 183 AA; 20936 MW; 3A78FE6F81D2E33E CRC64;
MTDQTYCDRL VQDTPFLTGQ GRLSEQQVDR IILQLNRYYP QILTNKEAEK FRNPKASLRV
RLCDLLSHLQ QRGERHCQEF YRALYIHAQP LHSHLPSRYS PQNSDCRELD WGIESRELSD
RGPMSFLAGL GLAAGLALLL YCCPPDPKVL PGTRRVLAFS PVIIDRHVSR YLLAFLADDL
GGL
