ID   Y2119_MYCPA             Reviewed;         412 AA.
AC   Q73Y38; Q9KII5;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=UPF0324 membrane protein MAP_2119;
GN   OrderedLocusNames=MAP_2119;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 19698 / CIP 103963 / DSM 44133 / TMC 807;
RX   PubMed=11549181; DOI=10.1099/0022-1317-50-9-795;
RA   Bannantine J.P., Stabel J.R.;
RT   "Identification of two Mycobacterium avium subspecies paratuberculosis gene
RT   products differentially recognised by sera from rabbits immunised with live
RT   mycobacteria but not heat-killed mycobacteria.";
RL   J. Med. Microbiol. 50:795-804(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0324 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF82075.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF232751; AAF82075.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE016958; AAS04436.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q73Y38; -.
DR   STRING; 262316.MAP_2119; -.
DR   EnsemblBacteria; AAS04436; AAS04436; MAP_2119.
DR   KEGG; mpa:MAP_2119; -.
DR   eggNOG; COG2855; Bacteria.
DR   HOGENOM; CLU_033541_1_0_11; -.
DR   OMA; IIVKMIR; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018383; UPF0324_pro.
DR   PANTHER; PTHR30106; PTHR30106; 1.
DR   Pfam; PF03601; Cons_hypoth698; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..412
FT                   /note="UPF0324 membrane protein MAP_2119"
FT                   /id="PRO_0000157428"
FT   TRANSMEM        67..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        215..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          14..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  43003 MW;  665113B3EC032E71 CRC64;
     MGGAAGVGFG GLVGHRGGGR DRRAGGGRRA PEGSVVTGVS TVRVAPDETD ETADATFTST
     RPLDYLPGIL LLIGVGVLGK YAQIWWNALA KHEHWTVPDI EYVLWAIVIG LVITNTVGLH
     PIFRPGVLTY EFWLKAGIVA LGSRFVLGDI AKLGGISLVQ ILVDMTIAGT IIIAVARWFG
     LSGKLGSLLA IGTSICGVSA IVAAKGAIRA RNSDVSYAIA AILALGAVSL FVLPPLGHAI
     GLTDHEFGLW AGLSVDNTAE TTATGYLYSE HAGKIAVLVK STRNALIGFV VLGFALFWAG
     RGQADEIAPG VRAKAAFIWA KFPKFVLGFL VVSAIATAGW LTKGQTANLA NVSKWAFLLT
     FAGVGLNTDI RQIARTGWRP LVVAVIGLTV VATVSLGIVL LTSRVFGWGV TT