ID   Y2125_METS5             Reviewed;         226 AA.
AC   A4YIL2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=UPF0173 metal-dependent hydrolase Msed_2125 {ECO:0000255|HAMAP-Rule:MF_00457};
GN   OrderedLocusNames=Msed_2125;
OS   Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509
OS   / TH2).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Metallosphaera.
OX   NCBI_TaxID=399549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2;
RX   PubMed=18083856; DOI=10.1128/aem.02019-07;
RA   Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT   "The genome sequence of the metal-mobilizing, extremely thermoacidophilic
RT   archaeon Metallosphaera sedula provides insights into bioleaching-
RT   associated metabolism.";
RL   Appl. Environ. Microbiol. 74:682-692(2008).
CC   -!- SIMILARITY: Belongs to the UPF0173 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00457}.
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DR   EMBL; CP000682; ABP96264.1; -; Genomic_DNA.
DR   RefSeq; WP_012022051.1; NC_009440.1.
DR   AlphaFoldDB; A4YIL2; -.
DR   SMR; A4YIL2; -.
DR   STRING; 399549.Msed_2125; -.
DR   EnsemblBacteria; ABP96264; ABP96264; Msed_2125.
DR   GeneID; 5104418; -.
DR   GeneID; 59456738; -.
DR   KEGG; mse:Msed_2125; -.
DR   eggNOG; arCOG00497; Archaea.
DR   HOGENOM; CLU_070010_4_0_2; -.
DR   OMA; WHGHSTW; -.
DR   Proteomes; UP000000242; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_00457; UPF0173; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR022877; UPF0173.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..226
FT                   /note="UPF0173 metal-dependent hydrolase Msed_2125"
FT                   /id="PRO_1000081125"
SQ   SEQUENCE   226 AA;  25078 MW;  7151A62ABAF71CCB CRC64;
     MSQIRWLGHA AVEILISGKR VIIDPLIKDN PLSPVKLNYL EGVSVVGVTH DHYDHLGDVV
     EILKMNSNAK LFATFDLEMY LVNQFKVPEA QLIPANVGGY VEHEGIRLAL TKAVHSSEHS
     DPTGIVVSDG RTTIYHAGDT GLFEDMKLIG QVFQPDYALL PIGGRFTMDP RQAVIAVDMI
     KPRKAAIPIH FNTWDMIRVD PQEFVKGVKD KGYEAILLQP GQSIEL