CAR3_DICDI
ID CAR3_DICDI Reviewed; 490 AA.
AC P35352; Q54YI3;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Cyclic AMP receptor 3;
DE Short=cAMP receptor 3;
GN Name=carC; Synonyms=car3; ORFNames=DDB_G0277829;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=8382181; DOI=10.1101/gad.7.2.273;
RA Johnson R.L., Saxe C.L. III, Gollop R., Kimmel A.R., Devreotes P.N.;
RT "Identification and targeted gene disruption of cAR3, a cAMP receptor
RT subtype expressed during multicellular stages of Dictyostelium
RT development.";
RL Genes Dev. 7:273-282(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Receptor for cAMP. Coordinates the aggregation of individual
CC cells into a multicellular organism and regulates the expression of a
CC large number of developmentally regulated genes. The activity of this
CC receptor is mediated by G proteins.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- DEVELOPMENTAL STAGE: Induced at early aggregation (6 hours) and
CC maximally expressed at the mound stage (9-12 hours), level of
CC expression peaks again during the slug stage (18 hours) and declines at
CC culmination.
CC -!- PTM: C-terminal Ser or Thr residues may be phosphorylated.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 5 family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-15 is the initiator.
CC {ECO:0000305}.
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DR EMBL; S55235; AAB25437.1; -; Genomic_DNA.
DR EMBL; AAFI02000023; EAL68087.1; -; Genomic_DNA.
DR RefSeq; XP_642219.1; XM_637127.1.
DR AlphaFoldDB; P35352; -.
DR SMR; P35352; -.
DR STRING; 44689.DDB0216181; -.
DR PaxDb; P35352; -.
DR EnsemblProtists; EAL68087; EAL68087; DDB_G0277829.
DR GeneID; 8621426; -.
DR KEGG; ddi:DDB_G0277829; -.
DR dictyBase; DDB_G0277829; carC.
DR eggNOG; ENOG502RYGP; Eukaryota.
DR HOGENOM; CLU_557157_0_0_1; -.
DR InParanoid; P35352; -.
DR OMA; ANTETYF; -.
DR PhylomeDB; P35352; -.
DR PRO; PR:P35352; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030552; F:cAMP binding; IDA:dictyBase.
DR GO; GO:0001646; F:cAMP receptor activity; IDA:dictyBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; IGI:dictyBase.
DR GO; GO:0090630; P:activation of GTPase activity; IMP:dictyBase.
DR GO; GO:0140582; P:adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway; IGI:dictyBase.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0031152; P:aggregation involved in sorocarp development; IGI:dictyBase.
DR GO; GO:0019934; P:cGMP-mediated signaling; IGI:dictyBase.
DR GO; GO:0006935; P:chemotaxis; IGI:dictyBase.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IMP:dictyBase.
DR InterPro; IPR022343; GCR1-cAMP_receptor.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000848; GPCR_cAMP.
DR PRINTS; PR02001; GCR1CAMPR.
DR PRINTS; PR00247; GPCRCAMP.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..490
FT /note="Cyclic AMP receptor 3"
FT /id="PRO_0000195082"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..192
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..235
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 236..246
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..271
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..490
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 303..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 204
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 490 AA; 56161 MW; A28BA834D8626153 CRC64;
MENLNTTSTA ALTGMTKQEN DASYAVLLIA DFTSIIGCTL VLLGFWRLKL LRNHITKIIT
FFCSTSLAKD LISTILTLIE KKQSNGSFQC YLYATVITYG SLACWLWTLC LSFSIYNLIV
KREPEPEKFE KYYHVFCWVV PFIMSVIMLS KGVIEVTGNW CWIGNTYVGY RFGLFYGPFL
AIWFLAAVLV GLTSRYTYKV IRSSVSDNKD RHMTYQFKLI NYIIVFLLCW VFAVINRIVN
GLNMFPAWVS ILHTYLSVSH GFYASVTFIY NNPLMWRYLA SIILIPFTKF GYFVETQQRL
EKNKNNNNHS PVGLSNNAQN NNHHHNHNNN HNNNHNNHNN NNNNNNSDFV NNDSSNYYTA
SMIESFSVQN ENSKSINGAD NFKQNGASQQ DDKDSPNSNN NNNNNNNNNN NNNNNNNNNN
NNNNYNNKDI EPIDNCNTNS IPMDNIATRI EIPPQHPTLT PQQSLQEINL NDDDNKINTH
QSNKKKDSNV
