ID   Y2127_STRCO             Reviewed;         191 AA.
AC   P40182;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Uncharacterized protein SCO2127;
GN   OrderedLocusNames=SCO2127; ORFNames=SC6E10.21c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE FUNCTION, POSSIBLE SUBUNIT, AND
RP   INDUCTION.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=1435260; DOI=10.1111/j.1365-2958.1992.tb01463.x;
RA   Angell S., Schwarz E., Bibb M.J.;
RT   "The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide
RT   sequence, transcriptional analysis and role in glucose repression.";
RL   Mol. Microbiol. 6:2833-2844(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: May be involved in glucose transport or metabolism.
CC       {ECO:0000305|PubMed:1435260}.
CC   -!- SUBUNIT: It may form a heterotetramer of two glucokinase subunits (glk)
CC       with two ORF2 proteins. {ECO:0000305|PubMed:1435260}.
CC   -!- INDUCTION: Transcribed at low levels from its own promoter. Transcript
CC       includes downstream gene glk. Expressed when grown on glucose or
CC       galactose, levels decrease as cells enter stationary phase.
CC       {ECO:0000269|PubMed:1435260}.
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DR   EMBL; X65932; CAA46726.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAB51975.1; -; Genomic_DNA.
DR   PIR; T35508; T35508.
DR   RefSeq; NP_626384.1; NC_003888.3.
DR   RefSeq; WP_011028152.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; P40182; -.
DR   SMR; P40182; -.
DR   STRING; 100226.SCO2127; -.
DR   GeneID; 1097561; -.
DR   KEGG; sco:SCO2127; -.
DR   PATRIC; fig|100226.15.peg.2162; -.
DR   eggNOG; ENOG50340VK; Bacteria.
DR   HOGENOM; CLU_120031_0_0_11; -.
DR   OMA; GQESRWT; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR035183; DUF5304.
DR   Pfam; PF17230; DUF5304; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Glucose metabolism; Reference proteome;
KW   Sugar transport; Transport.
FT   CHAIN           1..191
FT                   /note="Uncharacterized protein SCO2127"
FT                   /id="PRO_0000205345"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  20131 MW;  7CF36B2A7AC20044 CRC64;
     MSEELPPSEA PRPDEADAVD ETRATGETRG AAQEPGASDA DAWATACAED LEAEKARRRA
     AYGPPPGSAA EELRRLVDTV ADKLSGLQSP LLGQVAGPAA QQVVRQVVQQ AKAAVEPVIE
     RNPDLFDHLA AAGGELLAAY RSAVQNQERR WTTGDTAPKD PSDPRDLDER GTDGRDEGDG
     GTGPGQRIDL D