Y2140_MYCTU
ID Y2140_MYCTU Reviewed; 176 AA.
AC P9WFN1; L0T8Y7; O06235; P67226;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 41.
DE RecName: Full=UPF0098 protein Rv2140c;
GN OrderedLocusNames=Rv2140c; ORFNames=MTCY270.28;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- INTERACTION:
CC P9WFN1; P9WFN1: Rv2140c; NbExp=3; IntAct=EBI-6898684, EBI-6898684;
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC -!- SIMILARITY: Belongs to the UPF0098 family. {ECO:0000305}.
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DR EMBL; AL123456; CCP44915.1; -; Genomic_DNA.
DR PIR; H70577; H70577.
DR RefSeq; NP_216656.1; NC_000962.3.
DR RefSeq; WP_003411119.1; NZ_NVQJ01000044.1.
DR PDB; 4BEG; X-ray; 1.42 A; A/B=1-176.
DR PDBsum; 4BEG; -.
DR AlphaFoldDB; P9WFN1; -.
DR BMRB; P9WFN1; -.
DR SMR; P9WFN1; -.
DR MINT; P9WFN1; -.
DR STRING; 83332.Rv2140c; -.
DR iPTMnet; P9WFN1; -.
DR PaxDb; P9WFN1; -.
DR DNASU; 888118; -.
DR GeneID; 45426116; -.
DR GeneID; 888118; -.
DR KEGG; mtu:Rv2140c; -.
DR TubercuList; Rv2140c; -.
DR eggNOG; COG1881; Bacteria.
DR OMA; LAWDEVP; -.
DR PhylomeDB; P9WFN1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR CDD; cd00865; PEBP_bact_arch; 1.
DR Gene3D; 3.90.280.10; -; 1.
DR InterPro; IPR008914; PEBP.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR005247; YbhB_YbcL.
DR PANTHER; PTHR30289; PTHR30289; 1.
DR Pfam; PF01161; PBP; 1.
DR SUPFAM; SSF49777; SSF49777; 1.
DR TIGRFAMs; TIGR00481; TIGR00481; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:21969609"
FT CHAIN 2..176
FT /note="UPF0098 protein Rv2140c"
FT /id="PRO_0000137909"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0007744|PubMed:21969609"
FT TURN 7..10
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 18..20
FT /evidence="ECO:0007829|PDB:4BEG"
FT HELIX 32..34
FT /evidence="ECO:0007829|PDB:4BEG"
FT TURN 37..40
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 50..53
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 61..68
FT /evidence="ECO:0007829|PDB:4BEG"
FT TURN 72..75
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 77..86
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 129..142
FT /evidence="ECO:0007829|PDB:4BEG"
FT HELIX 152..162
FT /evidence="ECO:0007829|PDB:4BEG"
FT STRAND 163..174
FT /evidence="ECO:0007829|PDB:4BEG"
SQ SEQUENCE 176 AA; 18634 MW; E49A96E6DBE75520 CRC64;
MTTSPDPYAA LPKLPSFSLT STSITDGQPL ATPQVSGIMG AGGADASPQL RWSGFPSETR
SFAVTVYDPD APTLSGFWHW AVANLPANVT ELPEGVGDGR ELPGGALTLV NDAGMRRYVG
AAPPPGHGVH RYYVAVHAVK VEKLDLPEDA SPAYLGFNLF QHAIARAVIF GTYEQR
