ID   Y2143_MYCLE             Reviewed;         579 AA.
AC   O33057;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=Uncharacterized protein ML2143;
GN   OrderedLocusNames=ML2143; ORFNames=MLCB57.28c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.tuberculosis Rv0876c. {ECO:0000305}.
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DR   EMBL; Z99494; CAB16668.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31098.1; -; Genomic_DNA.
DR   PIR; T45344; T45344.
DR   RefSeq; NP_302414.1; NC_002677.1.
DR   AlphaFoldDB; O33057; -.
DR   STRING; 272631.ML2143; -.
DR   EnsemblBacteria; CAC31098; CAC31098; CAC31098.
DR   KEGG; mle:ML2143; -.
DR   PATRIC; fig|272631.5.peg.4047; -.
DR   Leproma; ML2143; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_025436_0_0_11; -.
DR   OMA; KAYGVVR; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..579
FT                   /note="Uncharacterized protein ML2143"
FT                   /id="PRO_0000103720"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        504..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   579 AA;  61707 MW;  B6797F5FA0B22799 CRC64;
     MSGRRRNHPG RLASIPGLRT RTGSRNQHPG IANYPADSSD FRPAQQRRAL EQREQQAGQL
     DPARRSPSMP SANRYLPPLG QQQSEPQHNS APPCGPYPGE RIKVTRAAAQ RSREMGYRMY
     WMVQRAATAD GADKSGLTAL TWPVVTNFAV DSAMAVALAN TLFFAAASGE SKSKVALYLL
     ITIAPFAVIA PLIGPALDRL QHGRRVALAT SFVLRTGLAT LLIMNYDGAT GSYPSMVLYP
     CALAMMVLSK SFSVLRSAVT PRVMPPSIDL VRVNSRLTVF GLLGGTIAGG AIAAGVEFVC
     AHLFKLPGAL FVVAAITISG ALLSMRIPRW VEVTAGEIPA TLSYRLHRKP LRQSWPEEVK
     KVSGRLRQPL GRNIITSLWG NCTIKVMVGF LFLYPAFVAK EHQANGWVQL GMLGLIGTAA
     AIGNFAGNFT SARLQLGRPA VLVVRCTIAV TVLALAASVA GNLLMTTIAT LITSGSSAIA
     KASLDASLQN DLPEESRASG FGRSESTLQL AWVLGGALGV MVYTDLWVGF TAVSALLILG
     LAQTVVSFRG DSLIPGLGGN RPVMIEQESM RRAAAVSPQ