ID   Y2145_STAHJ             Reviewed;         356 AA.
AC   Q4L4H1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Uncharacterized membrane protein SH2145;
GN   OrderedLocusNames=SH2145;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AP006716; BAE05454.1; -; Genomic_DNA.
DR   RefSeq; WP_011276407.1; NC_007168.1.
DR   AlphaFoldDB; Q4L4H1; -.
DR   SMR; Q4L4H1; -.
DR   STRING; 279808.SH2145; -.
DR   EnsemblBacteria; BAE05454; BAE05454; SH2145.
DR   GeneID; 58061727; -.
DR   KEGG; sha:SH2145; -.
DR   eggNOG; COG2199; Bacteria.
DR   HOGENOM; CLU_000445_11_1_9; -.
DR   OMA; FKQYKFQ; -.
DR   OrthoDB; 1635706at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   TIGRFAMs; TIGR00254; GGDEF; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="Uncharacterized membrane protein SH2145"
FT                   /id="PRO_0000286963"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          218..353
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00095"
SQ   SEQUENCE   356 AA;  40230 MW;  A711FE2B4CAA07D7 CRC64;
     MIESIIYNVA VMVAGIYLFH RLQYSENKIM VFSKGYVTVL MTIVALLLAA YPIPFHQEYL
     VHLTFVPLLF LGRFTNMGYT LVSAVIVALV EVFAFGNSLL YGVVLIVIGI IVSMVGPFLK
     QNDIVALVIL NLISVIILLI LSIFSPLYDL TEIAFLVPIS FVLTIASAIT FVDMWHFFSL
     VTRYENEDKY DYLTGLGNVK EFDRHLNHVS QIAEDKNESL ALLLIDIDGF KDVNDTYSHK
     SGDAVLKQMS QLLKNYVPKQ FQIFRNGGEE FSVVIRNYSL DQSVKLAENI RTGVEKSSFH
     LPNKEVIKLS VSIGVGYLSQ DDHKSQRKVF KDADDMVHVA KNEGRNQVMF NPIIKL