ID   Y214_PYRHO              Reviewed;         202 AA.
AC   O57953;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 105.
DE   RecName: Full=UPF0056 membrane protein PH0214;
GN   OrderedLocusNames=PH0214; ORFNames=PHBW009;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0056 (MarC) family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29283.1; -; Genomic_DNA.
DR   PIR; D71244; D71244.
DR   RefSeq; WP_010884322.1; NC_000961.1.
DR   AlphaFoldDB; O57953; -.
DR   TCDB; 2.A.95.1.2; the 6 tms neutral amino acid transporter (naat) family.
DR   EnsemblBacteria; BAA29283; BAA29283; BAA29283.
DR   GeneID; 1444104; -.
DR   KEGG; pho:PH0214; -.
DR   eggNOG; arCOG01997; Archaea.
DR   OMA; IRMIFPQ; -.
DR   OrthoDB; 99403at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002771; Multi_antbiot-R_MarC.
DR   PANTHER; PTHR33508; PTHR33508; 1.
DR   Pfam; PF01914; MarC; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="UPF0056 membrane protein PH0214"
FT                   /id="PRO_0000156920"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  21274 MW;  E6A34B52276FF06B CRC64;
     MLKEILSSAL LMLIMIDPSD KILLVSLLRE DFHIEDVKSL IIRANLIGFI LLLLFAVAGK
     IILQDIFHIE LDALRVAGGF VLFKIGLEAL EGGGMVTIKR EKNILALAAV PVATPLIAGP
     AAITAAITLT AEHGIIVSIV GTLIAIAITA ALMMIALYLM RGISKTALSV TIRIIGLFIM
     AIGAQMMITG AGGIVLNLIK GA