ID   Y2161_MYCVP             Reviewed;         279 AA.
AC   A1T726;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Uncharacterized oxidoreductase Mvan_2161;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Mvan_2161;
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; CP000511; ABM12976.1; -; Genomic_DNA.
DR   RefSeq; WP_011779390.1; NC_008726.1.
DR   AlphaFoldDB; A1T726; -.
DR   SMR; A1T726; -.
DR   STRING; 350058.Mvan_2161; -.
DR   EnsemblBacteria; ABM12976; ABM12976; Mvan_2161.
DR   KEGG; mva:Mvan_2161; -.
DR   eggNOG; COG0656; Bacteria.
DR   HOGENOM; CLU_023205_0_1_11; -.
DR   OMA; KLWPTDQ; -.
DR   OrthoDB; 1035565at2; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..279
FT                   /note="Uncharacterized oxidoreductase Mvan_2161"
FT                   /id="PRO_0000380750"
FT   ACT_SITE        54
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         112
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         192..244
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   279 AA;  29752 MW;  CCD7494B6063DD0D CRC64;
     MTSAAAIPTV ILNDDNTMPV IGLGVGELSD AEAEQSVLAA LEAGYRLIDT AAAYGNEAAV
     GRAIAKSGVP RGELFVTTKL ATDDLGFQSS QDALRASLER LGLDYVDLYL IHWPAGSQGT
     YVDSWGGLMK LKELGLTRSI GVSNFHAQHL DDIIGLSFFT PAVNQIELHP LLNQAELRAV
     NAEHGIVTEA YSPLGVGSLL SNPAVTAIAD AQDRTPAQVL IRWSLQLGNV VISRSSSPER
     IKSNLDVFDF ELTADQMAAL DGLDEGTRFR PDPETYTGS