ID   Y2172_SYMTH             Reviewed;         542 AA.
AC   Q67MD6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Uncharacterized transporter STH2172;
GN   OrderedLocusNames=STH2172;
OS   Symbiobacterium thermophilum (strain T / IAM 14863).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC   Symbiobacterium.
OX   NCBI_TaxID=292459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T / IAM 14863;
RX   PubMed=15383646; DOI=10.1093/nar/gkh830;
RA   Ueda K., Yamashita A., Ishikawa J., Shimada M., Watsuji T., Morimura K.,
RA   Ikeda H., Hattori M., Beppu T.;
RT   "Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium
RT   that depends on microbial commensalism.";
RL   Nucleic Acids Res. 32:4937-4944(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006840; BAD41157.1; -; Genomic_DNA.
DR   RefSeq; WP_011196297.1; NC_006177.1.
DR   AlphaFoldDB; Q67MD6; -.
DR   SMR; Q67MD6; -.
DR   STRING; 292459.STH2172; -.
DR   EnsemblBacteria; BAD41157; BAD41157; STH2172.
DR   KEGG; sth:STH2172; -.
DR   eggNOG; COG0569; Bacteria.
DR   eggNOG; COG2985; Bacteria.
DR   HOGENOM; CLU_035023_3_0_9; -.
DR   OMA; AMWLIRL; -.
DR   OrthoDB; 1458740at2; -.
DR   Proteomes; UP000000417; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR006512; YidE_YbjL.
DR   Pfam; PF06826; Asp-Al_Ex; 2.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   TIGRFAMs; TIGR01625; YidE_YbjL_dupl; 2.
DR   PROSITE; PS51202; RCK_C; 2.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..542
FT                   /note="Uncharacterized transporter STH2172"
FT                   /id="PRO_0000208780"
FT   TRANSMEM        4..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        519..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          186..270
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          273..356
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
SQ   SEQUENCE   542 AA;  58366 MW;  47FE6B8EA950DE77 CRC64;
     MLDILRDNPL LLLFIVAGIG YPLGRVRIGG IHLGVAAVLF VGLAFGALDP SLKLPEIVYQ
     FGLALFVYCV GLSSGHGFLR SFRGKGVIYN LLTLGVILLA AALLLIPHYL LSLRPGETAG
     VFAGLLTSTP ALAAAVEYLT RAGAAGQLSD PVVGYSIAYP ASVLGVILAI YLAERCFRID
     YRAEARTLKD VPGVSPEITC WTLRVCRPKA FGRTVRDLVA EHRLQVVFGR IRRGDHADVV
     SWETHLEEGD LVTAVGPVEE LERAAQVIGC VSEVQADLDR SEVDMREVFV SNPEVAGRTL
     RELNLPNRFG AVVSRVWRGD LQLLPYADMP LELGDRVRVL SRRERQQEVA AYLGDSYRAI
     SEIDIAVLGL GMALGIGLGL VPIPLPGGIT VRLGLAGGPL IVALFLGARQ RTGSLVWVLP
     YSANMLLRQM GLTIFLAAVG TRSGYEFAQM LTQPRGWAIL GASAAIIVLL SWVMLYVGYR
     WLRIPMGLLT GMVAGMQTQS ATLGFALDQA GNDLPTVGYA MVYPMAMVVK IVLAPVIIAV
     LT