ID   Y2179_DICDI             Reviewed;         145 AA.
AC   Q54SW1;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0282179;
DE   Flags: Precursor;
GN   ORFNames=DDB_G0282179;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC       and phosphatidylinositol. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000045; EAL66369.2; -; Genomic_DNA.
DR   RefSeq; XP_640348.2; XM_635256.2.
DR   AlphaFoldDB; Q54SW1; -.
DR   SMR; Q54SW1; -.
DR   STRING; 44689.DDB0205176; -.
DR   PaxDb; Q54SW1; -.
DR   EnsemblProtists; EAL66369; EAL66369; DDB_G0282179.
DR   GeneID; 8623448; -.
DR   KEGG; ddi:DDB_G0282179; -.
DR   dictyBase; DDB_G0282179; -.
DR   eggNOG; KOG4680; Eukaryota.
DR   HOGENOM; CLU_1790513_0_0_1; -.
DR   InParanoid; Q54SW1; -.
DR   OMA; LTCIAFD; -.
DR   PhylomeDB; Q54SW1; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8964038; LDL clearance.
DR   PRO; PR:Q54SW1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Lipid transport; Reference proteome; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..145
FT                   /note="Putative phosphatidylglycerol/phosphatidylinositol
FT                   transfer protein DDB_G0282179"
FT                   /id="PRO_0000389016"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   145 AA;  16156 MW;  9B090F365D47470D CRC64;
     MIKTILLLLI NFMLILIVNG DIWNYCDGNI NPTFKINKLT LLPDPPLVGK EVTISLEGSL
     NEQITSGSSI FNVAFFINGG WRQLPTFHND ICKVLSCPVS AGPFTYSTSI KVPIFTPHGQ
     YKGQLTLTDQ SNRNVTCLTF QTYLK