ID   Y2185_PYRAE             Reviewed;         350 AA.
AC   Q8ZVP4;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=UPF0219 protein PAE2185 {ECO:0000255|HAMAP-Rule:MF_01409};
GN   OrderedLocusNames=PAE2185;
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. UPF0219 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01409}.
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DR   EMBL; AE009441; AAL64012.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZVP4; -.
DR   SMR; Q8ZVP4; -.
DR   STRING; 178306.PAE2185; -.
DR   EnsemblBacteria; AAL64012; AAL64012; PAE2185.
DR   KEGG; pai:PAE2185; -.
DR   PATRIC; fig|178306.9.peg.1622; -.
DR   eggNOG; arCOG01767; Archaea.
DR   HOGENOM; CLU_039592_7_0_2; -.
DR   InParanoid; Q8ZVP4; -.
DR   OMA; YAKHKGK; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IBA:GO_Central.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IBA:GO_Central.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IBA:GO_Central.
DR   Gene3D; 3.40.47.10; -; 1.
DR   HAMAP; MF_01409; UPF0219; 1.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004656; FabH-rel.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020616; Thiolase_N.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   SUPFAM; SSF53901; SSF53901; 2.
DR   TIGRFAMs; TIGR00748; HMG_CoA_syn_Arc; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="UPF0219 protein PAE2185"
FT                   /id="PRO_0000057621"
SQ   SEQUENCE   350 AA;  38214 MW;  BE7F2760EFFF1C67 CRC64;
     MSKVGIVSWG AYIPKYRIRT EEVARIWGDD PLRIVDVYLV DEKSVESLDE DAVTIAVEAA
     RRALKRAGIN PKRIGAVYVG TESKPYAVKP ISSILVDALG LSNNVFAVDM EFACKAGSEG
     LVAAIGLVES GRIEYGMTVG TDTSQGEPGE HLEYSASSGG ASLIVGRDGV VAELEAVYSY
     VSDTPDFWRR EGSPYPMHGE GFTGEPAYFR HIIGAARGLM ERYGYKPSDF AYVVFHQPNG
     RFPVRAASML NIPMEKVKPG IVVTHIGNTY NASALMGFAK VLDIAKPGDK ILLVPFGSGA
     GSNAFVFTVT ELITERQKSG VPTVEDMLRD KIYIDYAQYL KMRKMIKLFE