ID   Y2188_DICDI             Reviewed;         750 AA.
AC   Q54DL7; B0G193;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=von Willebrand factor A domain-containing protein DDB_G0292188;
GN   ORFNames=DDB_G0292188;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDR41015.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAFI02000187; EDR41015.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AAFI02000187; EAL61450.1; -; Genomic_DNA.
DR   RefSeq; XP_001733056.1; XM_001733004.1.
DR   RefSeq; XP_629855.1; XM_629853.1.
DR   AlphaFoldDB; Q54DL7; -.
DR   STRING; 44689.DDB0234030; -.
DR   PaxDb; Q54DL7; -.
DR   EnsemblProtists; EAL61450; EAL61450; DDB_G0292188.
DR   EnsemblProtists; EDR41015; EDR41015; DDB_G0292188.
DR   GeneID; 8628536; -.
DR   KEGG; ddi:DDB_G0292188; -.
DR   dictyBase; DDB_G0292188; -.
DR   eggNOG; ENOG502RI33; Eukaryota.
DR   InParanoid; Q54DL7; -.
DR   OMA; EMNANDW; -.
DR   PhylomeDB; Q54DL7; -.
DR   PRO; PR:Q54DL7; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0072752; P:cellular response to rapamycin; IMP:dictyBase.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:dictyBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..750
FT                   /note="von Willebrand factor A domain-containing protein
FT                   DDB_G0292188"
FT                   /id="PRO_0000389209"
FT   DOMAIN          17..249
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          586..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..641
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  83699 MW;  6C551A00A0DA1909 CRC64;
     MFTENQNNNQ RHALKTEIKT VFNSDSGVTY FSILIETSSK MSLYNVIIKT FITQLQKANR
     ECQIQIITYG DSVNTIFEFD SEPNELKDSL KEIKFSKDNE EAKLGEAMRM CFNNIESNWS
     SDLMSKIIII SSGQSTDDSS DDLVDILSLD NNSIYGLAGC NLANKSSDEA VKDLQSLLPD
     QKVIPLGKNP SQDIRLLMNG GGGAANGGGA ANGASSSDEH SINCPVNIEV YPHTNETKSI
     KDDLLLDVVI KPDGNTASVP SGTKIKFLSN KYYSGYTIQL KQNLVFGEPY EETIKLEFKK
     GQMEKTQFEN FPSKIIFHIE LANDRDNVHE GFVALNISYF LGELKSKYRC CIGVEGEIGN
     GKSTCLNGFV NLFNPVGELE EYFNANRTSG THVTTSINNT SLKEILSAKH YIHPVQESFH
     DIDIAWSDSW GFVDTDVQLR HKAEGRIHHG TKKDECTILQ PDDRYRIDCF IFVVSIRNFT
     NPASMQRIEK KIKEVLQMNI TPLLAITFSD TLSKNQLQDV MKNKVAELSV QESNTFIISN
     YTEKETHKDI SKDVQYLRLL TKAVQLCKVK NEKDIMNKVK GISNLSINDN NNSFNQTPIK
     NQPFFESSST SSPSPAFFRS PIQQQQQQTS TTSTQSPSPS SSSASTPPPP SQMLNEQPSK
     TINVTIDVVT DSSGTVLTSF EIESSTNESV SELKCKLINE IDPEMNANDW SITKESGTVL
     FESARLSSII KSFDNSDSIK LVLKKKQKLF