ID   Y2191_MYCTO             Reviewed;         645 AA.
AC   P9WLJ0; L0TAG2; Q10384;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Putative bifunctional exonuclease/endonuclease protein MT2247 {ECO:0000305};
DE            EC=3.1.-.- {ECO:0000305};
GN   OrderedLocusNames=MT2247;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- DOMAIN: Seems to contain an N-terminal exonuclease domain and a C-
CC       terminal UvrC-like endonuclease domain. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46533.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46533.1; ALT_INIT; Genomic_DNA.
DR   PIR; H70783; H70783.
DR   RefSeq; WP_003901350.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLJ0; -.
DR   SMR; P9WLJ0; -.
DR   EnsemblBacteria; AAK46533; AAK46533; MT2247.
DR   KEGG; mtc:MT2247; -.
DR   PATRIC; fig|83331.31.peg.2423; -.
DR   HOGENOM; CLU_022933_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00573; dnaq; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   4: Predicted;
KW   Endonuclease; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease.
FT   CHAIN           1..645
FT                   /note="Putative bifunctional exonuclease/endonuclease
FT                   protein MT2247"
FT                   /id="PRO_0000427470"
FT   DOMAIN          44..207
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          248..326
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
FT   REGION          603..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   645 AA;  69180 MW;  EA89B536EE678A77 CRC64;
     MQGPNVAAMG ATGGTQLSFA DLAHAQGAAW TPADEMSLRE TTFVVVDLET TGGRTTGNDA
     TPPDAITEIG AVKVCGGAVL GEFATLVNPQ HSIPPQIVRL TGITTAMVGN APTIDAVLPM
     FFEFAGDSVL VAHNAGFDIG FLRAAARRCD ITWPQPQVLC TMRLARRVLS RDEAPSVRLA
     ALARLFAVAS NPTHRALDDA RATVDVLHAL IERVGNQGVH TYAELRSYLP NVTQAQRCKR
     VLAETLPHRP GVYLFRGPSG EVLYVGTAAD LRRRVSQYFN GTDRRKRMTE MVMLASSIDH
     VECAHPLEAG VRELRMLSTH APPYNRRSKF PYRWWWVALT DEAFPRLSVI RAPRHDRVVG
     PFRSRSKAAE TAALLARCTG LRTCTTRLTR SARHGPACPE LEVSACPAAR DVTAAQYAEA
     VLRAAALIGG LDNAALAAAV QQVTELAERR RYESAARLRD HLATAIEALW HGQRLRALAA
     LPELIAAKPD GPREGGYQLA VIRHGQLAAA GRAPRGVPPM PVVDAIRRGA QAILPTPAPL
     GGALVEEIAL IARWLAEPGV RIVGVSNDAA GLASPVRSAG PWAAWAATAR SAQLAGEQLS
     RGWQSDLPTE PHPSREQLFG RTGVDCRTGP PQPLLPGRQP FSTAG