ID   Y2191_MYCTU             Reviewed;         645 AA.
AC   P9WLJ1; L0TAG2; Q10384;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Putative bifunctional exonuclease/endonuclease protein Rv2191 {ECO:0000305};
DE            EC=3.1.-.- {ECO:0000305};
GN   OrderedLocusNames=Rv2191; ORFNames=MTCY190.02;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- DOMAIN: Seems to contain an N-terminal exonuclease domain and a C-
CC       terminal UvrC-like endonuclease domain. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44968.1; -; Genomic_DNA.
DR   PIR; H70783; H70783.
DR   RefSeq; NP_216707.1; NC_000962.3.
DR   RefSeq; WP_003901350.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WLJ1; -.
DR   SMR; P9WLJ1; -.
DR   STRING; 83332.Rv2191; -.
DR   PaxDb; P9WLJ1; -.
DR   DNASU; 887265; -.
DR   GeneID; 887265; -.
DR   KEGG; mtu:Rv2191; -.
DR   PATRIC; fig|83332.115.peg.2438; -.
DR   TubercuList; Rv2191; -.
DR   eggNOG; COG0322; Bacteria.
DR   eggNOG; COG0847; Bacteria.
DR   OMA; AVDHVEC; -.
DR   PhylomeDB; P9WLJ1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00573; dnaq; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   1: Evidence at protein level;
KW   Endonuclease; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..645
FT                   /note="Putative bifunctional exonuclease/endonuclease
FT                   protein Rv2191"
FT                   /id="PRO_0000103970"
FT   DOMAIN          44..207
FT                   /note="Exonuclease"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          248..326
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
FT   REGION          603..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   645 AA;  69180 MW;  EA89B536EE678A77 CRC64;
     MQGPNVAAMG ATGGTQLSFA DLAHAQGAAW TPADEMSLRE TTFVVVDLET TGGRTTGNDA
     TPPDAITEIG AVKVCGGAVL GEFATLVNPQ HSIPPQIVRL TGITTAMVGN APTIDAVLPM
     FFEFAGDSVL VAHNAGFDIG FLRAAARRCD ITWPQPQVLC TMRLARRVLS RDEAPSVRLA
     ALARLFAVAS NPTHRALDDA RATVDVLHAL IERVGNQGVH TYAELRSYLP NVTQAQRCKR
     VLAETLPHRP GVYLFRGPSG EVLYVGTAAD LRRRVSQYFN GTDRRKRMTE MVMLASSIDH
     VECAHPLEAG VRELRMLSTH APPYNRRSKF PYRWWWVALT DEAFPRLSVI RAPRHDRVVG
     PFRSRSKAAE TAALLARCTG LRTCTTRLTR SARHGPACPE LEVSACPAAR DVTAAQYAEA
     VLRAAALIGG LDNAALAAAV QQVTELAERR RYESAARLRD HLATAIEALW HGQRLRALAA
     LPELIAAKPD GPREGGYQLA VIRHGQLAAA GRAPRGVPPM PVVDAIRRGA QAILPTPAPL
     GGALVEEIAL IARWLAEPGV RIVGVSNDAA GLASPVRSAG PWAAWAATAR SAQLAGEQLS
     RGWQSDLPTE PHPSREQLFG RTGVDCRTGP PQPLLPGRQP FSTAG