Y2197_ARATH
ID Y2197_ARATH Reviewed; 365 AA.
AC P93749;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Probable protein kinase At2g41970;
DE EC=2.7.11.-;
GN OrderedLocusNames=At2g41970; ORFNames=T6D20.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; U90439; AAB63546.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10057.1; -; Genomic_DNA.
DR EMBL; BT010881; AAR24659.1; -; mRNA.
DR EMBL; AK175234; BAD42997.1; -; mRNA.
DR EMBL; AK175270; BAD43033.1; -; mRNA.
DR EMBL; AK176504; BAD44267.1; -; mRNA.
DR EMBL; AK176586; BAD44349.1; -; mRNA.
DR EMBL; AK176796; BAD44559.1; -; mRNA.
DR EMBL; AK220678; BAD93732.1; -; mRNA.
DR PIR; D84848; D84848.
DR RefSeq; NP_181728.1; NM_129761.3.
DR AlphaFoldDB; P93749; -.
DR SMR; P93749; -.
DR BioGRID; 4134; 1.
DR IntAct; P93749; 1.
DR STRING; 3702.AT2G41970.1; -.
DR PaxDb; P93749; -.
DR PRIDE; P93749; -.
DR ProteomicsDB; 242445; -.
DR EnsemblPlants; AT2G41970.1; AT2G41970.1; AT2G41970.
DR GeneID; 818797; -.
DR Gramene; AT2G41970.1; AT2G41970.1; AT2G41970.
DR KEGG; ath:AT2G41970; -.
DR Araport; AT2G41970; -.
DR TAIR; locus:2064557; AT2G41970.
DR eggNOG; KOG1187; Eukaryota.
DR HOGENOM; CLU_000288_21_4_1; -.
DR InParanoid; P93749; -.
DR OMA; SWNQRAK; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; P93749; -.
DR PRO; PR:P93749; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P93749; baseline and differential.
DR Genevisible; P93749; AT.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0009860; P:pollen tube growth; IMP:TAIR.
DR GO; GO:0048768; P:root hair cell tip growth; IMP:TAIR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Serine/threonine-protein kinase; Transferase;
KW Tyrosine-protein kinase.
FT CHAIN 1..365
FT /note="Probable protein kinase At2g41970"
FT /id="PRO_0000389478"
FT DOMAIN 73..354
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 204
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10028"
FT BINDING 79..87
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 146
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 208
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 239
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 244
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
FT MOD_RES 252
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:O48814"
SQ SEQUENCE 365 AA; 39378 MW; E0E260EC1112BB1F CRC64;
MFCCGGADEE PAGPPANQYA APPNKAGNPN FGGGNRGEPR NPNAPRSGAP AKVLPIEIPS
VALDELNRMA GNFGNKALIG EGSYGRVFCG KFKGEAVAIK KLDASSSEEP DSDFTSQLSV
VSRLKHDHFV ELLGYCLEAN NRILIYQFAT KGSLHDVLHG RKGVQGAEPG PVLNWNQRVK
IAYGAAKGLE FLHEKVQPPI VHRDVRSSNV LLFDDFVAKM ADFNLTNASS DTAARLHSTR
VLGTFGYHAP EYAMTGQITQ KSDVYSFGVV LLELLTGRKP VDHTMPKGQQ SLVTWATPRL
SEDKVKQCID PKLNNDFPPK AVAKLAAVAA LCVQYEADFR PNMTIVVKAL QPLLNSKPAG
PESTS
