Y219_RICPR
ID Y219_RICPR Reviewed; 412 AA.
AC O05945;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Uncharacterized zinc protease RP219;
DE EC=3.4.24.-;
GN OrderedLocusNames=RP219;
OS Rickettsia prowazekii (strain Madrid E).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=272947;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9274032; DOI=10.1099/00221287-143-8-2783;
RA Andersson J.O., Andersson S.G.E.;
RT "Genomic rearrangements during evolution of the obligate intracellular
RT parasite Rickettsia prowazekii as inferred from an analysis of 52015 bp
RT nucleotide sequence.";
RL Microbiology 143:2783-2795(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Madrid E;
RX PubMed=9823893; DOI=10.1038/24094;
RA Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA Kurland C.G.;
RT "The genome sequence of Rickettsia prowazekii and the origin of
RT mitochondria.";
RL Nature 396:133-140(1998).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the peptidase M16 family. {ECO:0000305}.
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DR EMBL; Y11780; CAA72467.1; -; Genomic_DNA.
DR EMBL; AJ235270; CAA14682.1; -; Genomic_DNA.
DR PIR; C71733; C71733.
DR RefSeq; NP_220605.1; NC_000963.1.
DR RefSeq; WP_004596018.1; NC_000963.1.
DR AlphaFoldDB; O05945; -.
DR SMR; O05945; -.
DR STRING; 272947.RP219; -.
DR MEROPS; M16.016; -.
DR EnsemblBacteria; CAA14682; CAA14682; CAA14682.
DR GeneID; 57569347; -.
DR KEGG; rpr:RP219; -.
DR PATRIC; fig|272947.5.peg.226; -.
DR eggNOG; COG0612; Bacteria.
DR HOGENOM; CLU_009902_3_0_5; -.
DR OMA; WSNPDNV; -.
DR Proteomes; UP000002480; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; SSF63411; 2.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome;
KW Zinc.
FT CHAIN 1..412
FT /note="Uncharacterized zinc protease RP219"
FT /id="PRO_0000074427"
FT ACT_SITE 52
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT BINDING 49
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT BINDING 53
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
FT BINDING 129
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10096"
SQ SEQUENCE 412 AA; 46611 MW; 29656AEB381031AE CRC64;
MKENFNVSKL KNGLTILTYN MPYVHSVAIN LIAKVGARYE NEEEEGISHF LEHMAFKGTK
TRTAQQIAEE FDSIGGYFNA YTGHENTVYY ARVLSENCHK ALNILADIIQ NSIFADEEIA
KEYQIIMQEI AHHHDNPDDL IYETFYNTVY KGQPLGKSIL GTTKTLVTFT KEHFLNFIGK
HYNAENLYLS IAGNIEHNKI VMIAEELFAS LKQGVKSSFI PAKYIGGKGF IHKELEQTSL
VLGFECTSYI NLGQLYQTYL LSIIFGGGMS SRLFQSIREK LGLAYVVGSY NSAYFDSGVF
TIYASTAHNK LELLYREIKN EIIKITETVS TEEIIRAKMQ LRSNLQMAQE QNTYKSEEIG
KNYSVFGKYI LPEEIIEIIT NIRADDIINT ANKIFSGTTT LAIIGPNDLN GF
