ID   Y2204_MYCTU             Reviewed;         118 AA.
AC   P9WMN5; L0TBT4; P0A5A9; Q10393;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Protein Rv2204c;
GN   OrderedLocusNames=Rv2204c; ORFNames=MTCY190.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11681203;
RX   DOI=10.1002/1615-9861(200104)1:4<494::aid-prot494>3.0.co;2-4;
RA   Mattow J., Jungblut P.R., Mueller E.-C., Kaufmann S.H.E.;
RT   "Identification of acidic, low molecular mass proteins of Mycobacterium
RT   tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization
RT   and electrospray ionization mass spectrometry.";
RL   Proteomics 1:494-507(2001).
RN   [3]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR
RP   METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44981.1; -; Genomic_DNA.
DR   PIR; E70785; E70785.
DR   RefSeq; NP_216720.1; NC_000962.3.
DR   RefSeq; WP_003411418.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WMN5; -.
DR   SMR; P9WMN5; -.
DR   STRING; 83332.Rv2204c; -.
DR   iPTMnet; P9WMN5; -.
DR   PaxDb; P9WMN5; -.
DR   DNASU; 888428; -.
DR   GeneID; 45426180; -.
DR   GeneID; 888428; -.
DR   KEGG; mtu:Rv2204c; -.
DR   TubercuList; Rv2204c; -.
DR   eggNOG; COG0316; Bacteria.
DR   OMA; YQLYFDE; -.
DR   PhylomeDB; P9WMN5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IBA:GO_Central.
DR   Gene3D; 2.60.300.12; -; 1.
DR   InterPro; IPR000361; FeS_biogenesis.
DR   InterPro; IPR016092; FeS_cluster_insertion.
DR   InterPro; IPR017870; FeS_cluster_insertion_CS.
DR   InterPro; IPR035903; HesB-like_dom_sf.
DR   Pfam; PF01521; Fe-S_biosyn; 1.
DR   SUPFAM; SSF89360; SSF89360; 1.
DR   TIGRFAMs; TIGR00049; TIGR00049; 1.
DR   PROSITE; PS01152; HESB; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0007744|PubMed:21969609"
FT   CHAIN           2..118
FT                   /note="Protein Rv2204c"
FT                   /id="PRO_0000077019"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0007744|PubMed:21969609"
SQ   SEQUENCE   118 AA;  12544 MW;  73B082E2B23F9993 CRC64;
     MTVQNEPSAK THGVILTEAA AAKAKSLLDQ EGRDDLALRI AVQPGGCAGL RYNLFFDDRT
     LDGDQTAEFG GVRLIVDRMS APYVEGASID FVDTIEKQGF TIDNPNATGS CACGDSFN