ID   Y2205_STRP1             Reviewed;         287 AA.
AC   P0C0G9; Q48W01; Q54615; Q99XH5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Putative sugar uptake protein SPy_2205/M5005_Spy1856;
GN   OrderedLocusNames=SPy_2205, M5005_Spy1856;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GRP transporter (TC 2.A.7.5) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK34833.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAZ52474.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004092; AAK34833.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP000017; AAZ52474.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_270112.1; NC_002737.2.
DR   AlphaFoldDB; P0C0G9; -.
DR   SMR; P0C0G9; -.
DR   STRING; 1314.HKU360_01966; -.
DR   PaxDb; P0C0G9; -.
DR   EnsemblBacteria; AAK34833; AAK34833; SPy_2205.
DR   KEGG; spy:SPy_2205; -.
DR   KEGG; spz:M5005_Spy1856; -.
DR   PATRIC; fig|160490.10.peg.1910; -.
DR   HOGENOM; CLU_076024_0_0_9; -.
DR   OMA; VNTKMGG; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR010651; Sugar_transport.
DR   PANTHER; PTHR16119; PTHR16119; 2.
DR   Pfam; PF06800; Sugar_transport; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..287
FT                   /note="Putative sugar uptake protein
FT                   SPy_2205/M5005_Spy1856"
FT                   /id="PRO_0000213663"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   287 AA;  31222 MW;  3C62440F18F7E5A2 CRC64;
     MEGIFYALIP MFTWGSIGFV SNKIGGKPSQ QTLGMTFGAL LFSLAVWLIV RPEMTLQLWL
     FGILGGFIWS IGQTGQFHAM QYMGVSVANP LSSGSQLVLG SLIGVLVFHE WTRPMQFVVG
     SLALLLLIVG FYFSSKQDDA NAQVNHLHNF SKGFRALTYS TIGYVMYAVL FNNIMKFEVL
     SVILPMAVGM VLGAITFMSF KISIDQYVIK NSVVGLLWGI GNIFMLLAAS KAGLAIAFSF
     SQLGAIISIV GGILFLGETK TKKEMRWVVT GIICFIVGAI LLGVVKS