ID   Y2212_MYCTO             Reviewed;         378 AA.
AC   P9WMU6; L0T8Y3; P64265; Q10400;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein MT2268;
GN   OrderedLocusNames=MT2268;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46554.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46554.1; ALT_INIT; Genomic_DNA.
DR   PIR; E70786; E70786.
DR   RefSeq; WP_003411442.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMU6; -.
DR   SMR; P9WMU6; -.
DR   EnsemblBacteria; AAK46554; AAK46554; MT2268.
DR   GeneID; 45426188; -.
DR   KEGG; mtc:MT2268; -.
DR   PATRIC; fig|83331.31.peg.2443; -.
DR   HOGENOM; CLU_043761_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..378
FT                   /note="Uncharacterized protein MT2268"
FT                   /id="PRO_0000427240"
FT   DOMAIN          208..317
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   378 AA;  39775 MW;  AF26A9CFC13C91DC CRC64;
     MYDSLDFDAL EAAGIANPRE RAGLLTYLDE LGFTVEEMVQ AERRGRLFGL AGDVLLWSGP
     PIYTLATAAD ELGLSADDVA RAWSLLGLTV AGPDVPTLSQ ADVDALATWV ALKALVGEDG
     AFGLLRVLGT AMARLAEAES TMIRAGSPNI QMTHTHDELA TARAYRAAAE FVPRIGALID
     TVHRHHLASA RTYFEGVIGD TSASVTCGIG FADLSSFTAL TQALTPAQLQ DLLTEFDAAV
     TDVVHADGGR LVKFIGDAVM WVSSSPERLV RAAVDLVDHP GARAAELQVR AGLAYGTVLA
     LNGDYFGNPV NLAARLVAAA APGQILAAAQ LRDMLPDWPA LAHGPLTLKG FDAPVMAFEL
     HDNPRARDAD TPSPAASD