ID   Y2212_MYCTU             Reviewed;         378 AA.
AC   P9WMU7; L0T8Y3; P64265; Q10400;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Uncharacterized protein Rv2212;
GN   OrderedLocusNames=Rv2212; ORFNames=MTCY190.23;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
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DR   EMBL; AL123456; CCP44989.1; -; Genomic_DNA.
DR   PIR; E70786; E70786.
DR   RefSeq; NP_216728.1; NC_000962.3.
DR   RefSeq; WP_003411442.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WMU7; -.
DR   SMR; P9WMU7; -.
DR   STRING; 83332.Rv2212; -.
DR   PaxDb; P9WMU7; -.
DR   DNASU; 887979; -.
DR   GeneID; 45426188; -.
DR   GeneID; 887979; -.
DR   KEGG; mtu:Rv2212; -.
DR   TubercuList; Rv2212; -.
DR   eggNOG; COG2114; Bacteria.
DR   OMA; IGDEVMW; -.
DR   PhylomeDB; P9WMU7; -.
DR   BRENDA; 4.6.1.1; 3445.
DR   PHI-base; PHI:7045; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:MTBBASE.
DR   GO; GO:0005504; F:fatty acid binding; IDA:MTBBASE.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IDA:MTBBASE.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..378
FT                   /note="Uncharacterized protein Rv2212"
FT                   /id="PRO_0000074132"
FT   DOMAIN          208..317
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   378 AA;  39775 MW;  AF26A9CFC13C91DC CRC64;
     MYDSLDFDAL EAAGIANPRE RAGLLTYLDE LGFTVEEMVQ AERRGRLFGL AGDVLLWSGP
     PIYTLATAAD ELGLSADDVA RAWSLLGLTV AGPDVPTLSQ ADVDALATWV ALKALVGEDG
     AFGLLRVLGT AMARLAEAES TMIRAGSPNI QMTHTHDELA TARAYRAAAE FVPRIGALID
     TVHRHHLASA RTYFEGVIGD TSASVTCGIG FADLSSFTAL TQALTPAQLQ DLLTEFDAAV
     TDVVHADGGR LVKFIGDAVM WVSSSPERLV RAAVDLVDHP GARAAELQVR AGLAYGTVLA
     LNGDYFGNPV NLAARLVAAA APGQILAAAQ LRDMLPDWPA LAHGPLTLKG FDAPVMAFEL
     HDNPRARDAD TPSPAASD