Y2213_MYCBO
ID Y2213_MYCBO Reviewed; 385 AA.
AC P67474; A0A1R3Y0F6; O53524; Q10383; X2BJK7;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Probable endopeptidase Mb2213c;
DE EC=3.4.-.-;
GN OrderedLocusNames=BQ2027_MB2213C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- SIMILARITY: Belongs to the peptidase C40 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01284, ECO:0000305}.
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DR EMBL; LT708304; SIU00821.1; -; Genomic_DNA.
DR RefSeq; NP_855862.1; NC_002945.3.
DR RefSeq; WP_003411373.1; NC_002945.4.
DR AlphaFoldDB; P67474; -.
DR SMR; P67474; -.
DR EnsemblBacteria; SIU00821; SIU00821; BQ2027_MB2213C.
DR PATRIC; fig|233413.5.peg.2428; -.
DR OMA; GYAMQFQ; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protease; Thiol protease.
FT CHAIN 1..385
FT /note="Probable endopeptidase Mb2213c"
FT /id="PRO_0000109874"
FT DOMAIN 270..385
FT /note="NlpC/P60"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT REGION 235..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..261
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 300
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
FT ACT_SITE 360
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01284"
SQ SEQUENCE 385 AA; 39756 MW; 0F8F26577D0468DA CRC64;
MRLDQRWLIA RVIMRSAIGF FASFTVSSGV LAANVLADPA DDALAKLNEL SRQAEQTTEA
LHSAQLDLNE KLAAQRAADQ KLADNRTALD AARARLATFQ TAVNKVAAAT YMGGRTHGMD
AILTAESPQL LIDRLSVQRV MAHQMSTQMA RFKAAGEQAV KAEQAAAKSA ADARSAAEQA
AAVRANLQHK QSQLQVQIAV VKSQYVALTP EERTALADPG PVPAVAAIAP GAPPAALPPG
APPGDGPAPG VAPPPGGMPG LPFVQPDGAG GDRTAVVQAA LTQVGAPYAW GGAAPGGFDC
SGLVMWAFQQ AGIALPHSSQ ALAHGGQPVA LSDLQPGDVL TFYSDASHAG IYIGDGLMVH
SSTYGVPVRV VPMDSSGPIY DARRY
