Y2214_ARATH
ID Y2214_ARATH Reviewed; 871 AA.
AC Q9SJT0;
DT 13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Probable receptor-like protein kinase At2g21480;
DE EC=2.7.11.-;
DE Flags: Precursor;
GN OrderedLocusNames=At2g21480; ORFNames=F3K23.24;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=19529822; DOI=10.1093/mp/ssn083;
RA Chae L., Sudat S., Dudoit S., Zhu T., Luan S.;
RT "Diverse transcriptional programs associated with environmental stress and
RT hormones in the Arabidopsis receptor-like kinase gene family.";
RL Mol. Plant 2:84-107(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AC006841; AAD23692.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07184.1; -; Genomic_DNA.
DR PIR; G84601; G84601.
DR RefSeq; NP_179743.1; NM_127720.2.
DR AlphaFoldDB; Q9SJT0; -.
DR SMR; Q9SJT0; -.
DR STRING; 3702.AT2G21480.1; -.
DR iPTMnet; Q9SJT0; -.
DR PaxDb; Q9SJT0; -.
DR PRIDE; Q9SJT0; -.
DR ProteomicsDB; 242989; -.
DR EnsemblPlants; AT2G21480.1; AT2G21480.1; AT2G21480.
DR GeneID; 816687; -.
DR Gramene; AT2G21480.1; AT2G21480.1; AT2G21480.
DR KEGG; ath:AT2G21480; -.
DR Araport; AT2G21480; -.
DR TAIR; locus:2050080; AT2G21480.
DR eggNOG; KOG1187; Eukaryota.
DR HOGENOM; CLU_000288_42_1_1; -.
DR InParanoid; Q9SJT0; -.
DR OMA; GKNMPPL; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; Q9SJT0; -.
DR PRO; PR:Q9SJT0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SJT0; baseline and differential.
DR Genevisible; Q9SJT0; AT.
DR GO; GO:0016324; C:apical plasma membrane; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IBA:GO_Central.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0046777; P:protein autophosphorylation; IBA:GO_Central.
DR GO; GO:0080092; P:regulation of pollen tube growth; IGI:TAIR.
DR InterPro; IPR045272; ANXUR1-like.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024788; Malectin-like_Carb-bd_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27003; PTHR27003; 1.
DR Pfam; PF12819; Malectin_like; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding; Glycoprotein; Kinase; Membrane; Nucleotide-binding;
KW Reference proteome; Serine/threonine-protein kinase; Signal; Transferase;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..871
FT /note="Probable receptor-like protein kinase At2g21480"
FT /id="PRO_0000386552"
FT TOPO_DOM 40..439
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 461..871
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 525..797
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 808..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 649
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT ECO:0000255|PROSITE-ProRule:PRU10027"
FT BINDING 531..539
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 553
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 871 AA; 95936 MW; 9A8F5658104D547E CRC64;
MEIRKKPNIP MCLVLDSSSR PFMTLLFTIL LFLTGLASAV GAVGGSPTAG FKPADDILID
CGSKSSTKTP EGRVFKSDSE TVQYIEAKDD IQVSAPPSDK LPSPIYLTAK IFREEAIYKF
HLTRPGWHWV RLHFFAFPND KFDLQQATFS VLTEKYVLLH NFKLSNDNND SQATVQKEYL
LNMTDAQFAL RFKPMKGSAA FINGIELVSA PDELISDAGT SLFPVNGFSG LSDYAYQSVY
RVNVGGPLIT PQNDTLGRTW TPDKEYLKDE NLAKDVKTNP TAIIYPPGVT PLIAPQTVYA
TGAEMADSQT IDPNFNVTWN FPSNPSFHYF IRLHFCDIIS KSLNDLYFNV YINGKTAISG
LDLSTVAGDL SAPYYKDIVV NSTLMTSELQ VQIGPMGEDT GKKNAILNGV EVLKMSNSVN
SLDGEFGVDG QRASMGKQGM VATAGFVMMF GAFVGLGAMV YKWKKRPQDW QKRNSFSSWL
LPIHAGDSTF MTSKTGSHKS NLYNSALGLG RYFSLSELQE VTKNFDASEI IGVGGFGNVY
IGTIDDGTQV AIKRGNPQSE QGITEFHTEI QMLSKLRHRH LVSLIGYCDE NAEMILVYEY
MSNGPFRDHL YGKNLSPLTW KQRLEICIGA ARGLHYLHTG TAQGIIHRDV KSTNILLDEA
LVAKVADFGL SKDVAFGQNH VSTAVKGSFG YLDPEYFRRQ QLTDKSDVYS FGVVLLEALC
ARPAINPQLP REQVNLAEWA MLWKQKGLLE KIIDPHLVGA VNPESMKKFA EAAEKCLADY
GVDRPTMGDV LWNLEYALQL QEAFSQGKAE AEEVETPKPV AVPAAAPTSP AATTAAASER
PVSQTEEKDD STVDQHSGTT MFTQFASLNG R
