ID   Y2216_MYCTU             Reviewed;         301 AA.
AC   P9WGP7; L0TAI8; P67232; Q10403;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Epimerase family protein Rv2216;
GN   OrderedLocusNames=Rv2216; ORFNames=MTCY190.27;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. SDR39U1 subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP44993.1; -; Genomic_DNA.
DR   PIR; A70787; A70787.
DR   RefSeq; NP_216732.1; NC_000962.3.
DR   RefSeq; WP_003411454.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WGP7; -.
DR   SMR; P9WGP7; -.
DR   STRING; 83332.Rv2216; -.
DR   PaxDb; P9WGP7; -.
DR   DNASU; 887640; -.
DR   GeneID; 45426192; -.
DR   GeneID; 887640; -.
DR   KEGG; mtu:Rv2216; -.
DR   TubercuList; Rv2216; -.
DR   eggNOG; COG1090; Bacteria.
DR   OMA; YMPWIHI; -.
DR   PhylomeDB; P9WGP7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0036199; F:cholest-4-en-3-one 26-monooxygenase activity; IDA:MTBBASE.
DR   GO; GO:0031073; F:cholesterol 26-hydroxylase activity; IDA:MTBBASE.
DR   GO; GO:0020037; F:heme binding; IDA:MTBBASE.
DR   GO; GO:0006707; P:cholesterol catabolic process; IDA:MTBBASE.
DR   InterPro; IPR013549; DUF1731.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR010099; SDR39U1.
DR   Pfam; PF08338; DUF1731; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01777; yfcH; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..301
FT                   /note="Epimerase family protein Rv2216"
FT                   /id="PRO_0000162407"
SQ   SEQUENCE   301 AA;  31672 MW;  26CD511BE6A437FE CRC64;
     MANAVVAIAG SSGLIGSALT AALRAADHTV LRIVRRAPAN SEELHWNPES GEFDPHALTD
     VDAVVNLCGV NIAQRRWSGA FKQSLRDSRI TPTEVLSAAV ADAGVATLIN ASAVGYYGNT
     KDRVVDENDS AGTGFLAQLC VDWETATRPA QQSGARVVLA RTGVVLSPAG GMLRRMRPLF
     SVGLGARLGS GRQYMSWISL EDEVRALQFA IAQPNLSGPV NLTGPAPVTN AEFTTAFGRA
     VNRPTPLMLP SVAVRAAFGE FADEGLLIGQ RAIPSALERA GFQFHHNTIG EALGYATTRP
     G