ID   Y2219_MYCTU             Reviewed;         250 AA.
AC   P9WLI1; L0TBU9; Q10405;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized protein Rv2219;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2219; ORFNames=MTCY190.30;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP44996.1; -; Genomic_DNA.
DR   PIR; D70787; D70787.
DR   RefSeq; NP_216735.1; NC_000962.3.
DR   RefSeq; WP_003411463.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WLI1; -.
DR   STRING; 83332.Rv2219; -.
DR   PaxDb; P9WLI1; -.
DR   DNASU; 888380; -.
DR   GeneID; 45426195; -.
DR   GeneID; 888380; -.
DR   KEGG; mtu:Rv2219; -.
DR   PATRIC; fig|83332.111.peg.2466; -.
DR   TubercuList; Rv2219; -.
DR   eggNOG; ENOG5031K3Y; Bacteria.
DR   OMA; GDLMSNM; -.
DR   PhylomeDB; P9WLI1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR025445; DUF4191.
DR   Pfam; PF13829; DUF4191; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..250
FT                   /note="Uncharacterized protein Rv2219"
FT                   /id="PRO_0000014126"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          226..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   250 AA;  26864 MW;  ADC433144243095C CRC64;
     MAKPRNAAES KAAKAQANAA RKAAARQRRA QLWQAFTLQR KEDKRLLPYM IGAFLLIVGA
     SVGVGVWAGG FTMFTMIPLG VLLGALVAFV IFGRRAQRTV YRKAEGQTGA AAWALDNLRG
     KWRVTPGVAA TGNLDAVHRV IGRPGVIFVG EGSAARVKPL LAQEKKRTAR LVGDVPIYDI
     IVGNGDGEVP LAKLERHLTR LPANITVKQM DTVESRLAAL GSRAGAGVMP KGPLPTTAKM
     RSVQRTVRRK