ID   Y2228_MYCTO             Reviewed;         364 AA.
AC   P9WLH4; L0TBW1; P64955; Q10512;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Uncharacterized protein MT2287;
GN   OrderedLocusNames=MT2287;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46573.1; -; Genomic_DNA.
DR   PIR; H70776; H70776.
DR   RefSeq; WP_003899226.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLH4; -.
DR   SMR; P9WLH4; -.
DR   EnsemblBacteria; AAK46573; AAK46573; MT2287.
DR   GeneID; 45426206; -.
DR   KEGG; mtc:MT2287; -.
DR   PATRIC; fig|83331.31.peg.2462; -.
DR   HOGENOM; CLU_035712_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd07067; HP_PGM_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   InterPro; IPR013078; His_Pase_superF_clade-1.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00300; His_Phos_1; 1.
DR   Pfam; PF13456; RVT_3; 1.
DR   PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR   SMART; SM00855; PGAM; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
FT   CHAIN           1..364
FT                   /note="Uncharacterized protein MT2287"
FT                   /id="PRO_0000427478"
FT   DOMAIN          1..139
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00408"
SQ   SEQUENCE   364 AA;  39145 MW;  A78E00C9E7D42F9E CRC64;
     MKVVIEADGG SRGNPGPAGY GAVVWTADHS TVLAESKQAI GRATNNVAEY RGLIAGLDDA
     VKLGATEAAV LMDSKLVVEQ MSGRWKVKHP DLLKLYVQAQ ALASQFRRIN YEWVPRARNT
     YADRLANDAM DAAAQSAAAD ADPAKIVATE SPTSPGWTGA RGTPTRLLLL RHGQTELSEQ
     RRYSGRGNPG LNEVGWRQVG AAAGYLARRG GIAAVVSSPL QRAYDTAVTA ARALALDVVV
     DDDLVETDFG AWEGLTFAEA AERDPELHRR WLQDTSITPP GGESFDDVLR RVRRGRDRII
     VGYEGATVLV VSHVTPIKML LRLALDAGSG VLYRLHLDLA SLSIAEFYAD GASSVRLVNQ
     TGYL