ID   Y2235_MYCBO             Reviewed;         378 AA.
AC   P64266; A0A1R3Y0I6; Q10400; X2BK46;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Uncharacterized protein Mb2235;
GN   OrderedLocusNames=BQ2027_MB2235;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
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DR   EMBL; LT708304; SIU00843.1; -; Genomic_DNA.
DR   RefSeq; NP_855884.1; NC_002945.3.
DR   RefSeq; WP_003411442.1; NC_002945.4.
DR   AlphaFoldDB; P64266; -.
DR   SMR; P64266; -.
DR   EnsemblBacteria; SIU00843; SIU00843; BQ2027_MB2235.
DR   GeneID; 45426188; -.
DR   PATRIC; fig|233413.5.peg.2451; -.
DR   OMA; IGDEVMW; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..378
FT                   /note="Uncharacterized protein Mb2235"
FT                   /id="PRO_0000074133"
FT   DOMAIN          208..317
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   378 AA;  39775 MW;  AF26A9CFC13C91DC CRC64;
     MYDSLDFDAL EAAGIANPRE RAGLLTYLDE LGFTVEEMVQ AERRGRLFGL AGDVLLWSGP
     PIYTLATAAD ELGLSADDVA RAWSLLGLTV AGPDVPTLSQ ADVDALATWV ALKALVGEDG
     AFGLLRVLGT AMARLAEAES TMIRAGSPNI QMTHTHDELA TARAYRAAAE FVPRIGALID
     TVHRHHLASA RTYFEGVIGD TSASVTCGIG FADLSSFTAL TQALTPAQLQ DLLTEFDAAV
     TDVVHADGGR LVKFIGDAVM WVSSSPERLV RAAVDLVDHP GARAAELQVR AGLAYGTVLA
     LNGDYFGNPV NLAARLVAAA APGQILAAAQ LRDMLPDWPA LAHGPLTLKG FDAPVMAFEL
     HDNPRARDAD TPSPAASD