ID   Y2237_MYCTU             Reviewed;         255 AA.
AC   P9WLH1; L0TBX1; P64957; Q10519;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized protein Rv2237;
GN   OrderedLocusNames=Rv2237; ORFNames=MTCY427.18;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP45016.1; -; Genomic_DNA.
DR   PIR; A70778; A70778.
DR   RefSeq; NP_216753.1; NC_000962.3.
DR   RefSeq; WP_003901356.1; NC_000962.3.
DR   AlphaFoldDB; P9WLH1; -.
DR   SMR; P9WLH1; -.
DR   STRING; 83332.Rv2237; -.
DR   PaxDb; P9WLH1; -.
DR   PRIDE; P9WLH1; -.
DR   DNASU; 887840; -.
DR   GeneID; 887840; -.
DR   KEGG; mtu:Rv2237; -.
DR   PATRIC; fig|83332.111.peg.2490; -.
DR   TubercuList; Rv2237; -.
DR   eggNOG; COG3662; Bacteria.
DR   OMA; QVPERMW; -.
DR   PhylomeDB; P9WLH1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   InterPro; IPR018713; MPAB/Lcp_cat_dom.
DR   Pfam; PF09995; MPAB_Lcp_cat; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..255
FT                   /note="Uncharacterized protein Rv2237"
FT                   /id="PRO_0000103985"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   255 AA;  29067 MW;  B0F422277C6B46A6 CRC64;
     MLLPAANVIM QLAVPGVGYG VLESPVDSGN VYKHPFKRAR TTGTYLAVAT IGTESDRALI
     RGAVDVAHRQ VRSTASSPVS YNAFDPKLQL WVAACLYRYF VDQHEFLYGP LEDATADAVY
     QDAKRLGTTL QVPEGMWPPD RVAFDEYWKR SLDGLQIDAP VREHLRGVAS VAFLPWPLRA
     VAGPFNLFAT TGFLAPEFRA MMQLEWSQAQ QRRFEWLLSV LRLADRLIPH RAWIFVYQLY
     LWDMRFRARH GRRIV