ID   Y2246_METAC             Reviewed;         426 AA.
AC   Q8TNN7;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Uncharacterized serpin-like protein MA_2246;
GN   OrderedLocusNames=MA_2246;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AE010299; AAM05641.1; -; Genomic_DNA.
DR   RefSeq; WP_011022227.1; NC_003552.1.
DR   AlphaFoldDB; Q8TNN7; -.
DR   SMR; Q8TNN7; -.
DR   MEROPS; I04.089; -.
DR   EnsemblBacteria; AAM05641; AAM05641; MA_2246.
DR   GeneID; 1474134; -.
DR   KEGG; mac:MA_2246; -.
DR   HOGENOM; CLU_023330_0_2_2; -.
DR   InParanoid; Q8TNN7; -.
DR   OMA; PICIYRN; -.
DR   OrthoDB; 72278at2157; -.
DR   PhylomeDB; Q8TNN7; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..426
FT                   /note="Uncharacterized serpin-like protein MA_2246"
FT                   /id="PRO_0000094160"
FT   SITE            384..385
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   426 AA;  48271 MW;  7DFD3ADB3B60D3AD CRC64;
     MTKCKIILVI SLSILALLCI GCIENSTINT KTTVNSTVDT KTIINTDSVE EYDIATANNA
     FTFDLYSMVK NEDENVLFSP YSIFSAMAVC YDGTEGSTKE QMSNAFYYPL NKLVLEESSK
     KMIGTINSNN DAYDLETTNA LWVLENYTLN EQYVSNAKNY YDGMVTPVDF VNEPEASTDT
     INKWVEEKTN EKIKKLIPEG EIGPDTRLVI TNTIYFNGTW VKEFDPDITR TRSFTLSNGD
     EKSVSTMRIV EKFNYGEDQK AKILELPYKG DNLSMYIVLP KENNITELEN NFTLKYYSKL
     KENMSTGDYV EVWIPKFTFK TEAELKSPLI EMGVVDAFNP NAANFSGITP DKSLAISEIY
     HQAFVDVHEK GTEAAAATGA IILEEEIEYT WEFKADHPFL FMIEDKRTGC ILFIGKVESP
     EYEKMS