ID   Y224_MYCTU              Reviewed;         254 AA.
AC   P9WJZ9; L0T5V2; P96406; Q7DA86;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized methyltransferase Rv0224c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv0224c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP42952.1; -; Genomic_DNA.
DR   PIR; F70961; F70961.
DR   RefSeq; NP_214738.1; NC_000962.3.
DR   RefSeq; WP_003401240.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WJZ9; -.
DR   STRING; 83332.Rv0224c; -.
DR   PaxDb; P9WJZ9; -.
DR   DNASU; 886715; -.
DR   GeneID; 886715; -.
DR   KEGG; mtu:Rv0224c; -.
DR   TubercuList; Rv0224c; -.
DR   eggNOG; COG0500; Bacteria.
DR   OMA; TNWLSPW; -.
DR   PhylomeDB; P9WJZ9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..254
FT                   /note="Uncharacterized methyltransferase Rv0224c"
FT                   /id="PRO_0000380608"
SQ   SEQUENCE   254 AA;  27511 MW;  E2C4C10EBF3D2161 CRC64;
     MAVTDVFARR ATLRRSLRLL ADFRYEQRDP ARFYRTLAAD TAAMIGDLWL ATHSEPPVGR
     TLLDVGGGPG YFATAFSDAG VGYIGVEPDP DEMHAAGPAF TGRPGMFVRA SGMALPFADD
     SVDICLSSNV AEHVPRPWQL GTEMLRVTKP GGLVVLSYTV WLGPFGGHEM GLSHYLGGAR
     AAARYVRKHG HPAKNNYGSS LFAVSAAEGL RWAAGTGAAL AVFPRYHPRW AWWLTSVPVL
     REFLVSNLVL VLTP