ID   Y2250_MYCTO             Reviewed;         189 AA.
AC   P9WMC4; L0T996; Q10528;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT2310;
GN   OrderedLocusNames=MT2310;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK46594.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK46594.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70779; F70779.
DR   RefSeq; WP_003411595.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMC4; -.
DR   SMR; P9WMC4; -.
DR   EnsemblBacteria; AAK46594; AAK46594; MT2310.
DR   GeneID; 45426230; -.
DR   KEGG; mtc:MT2310; -.
DR   PATRIC; fig|83331.31.peg.2487; -.
DR   HOGENOM; CLU_069356_39_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..189
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT2310"
FT                   /id="PRO_0000427328"
FT   DOMAIN          9..69
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   189 AA;  20494 MW;  C83E52A90C45C214 CRC64;
     MLSMSNDRAD TGGRILRAAA SCVVDYGVDR VTLAEIARRA GVSRPTVYRR WPDTRSIMAS
     MLTSHIADVL REVPLDGDDR EALVKQIVAV ADRLRGDDLI MSVMHSELAR VYITERLGTS
     QQVLIEGLAA RLTVAQRSGS VRSGDARRLA TMVLLIAQST IQSADIVDSI LDSAALATEL
     THALNGYLC