ID   Y2250_MYCTU             Reviewed;         189 AA.
AC   P9WMC5; L0T996; Q10528;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv2250c;
GN   OrderedLocusNames=Rv2250c; ORFNames=MTCY427.32c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP45030.1; -; Genomic_DNA.
DR   PIR; F70779; F70779.
DR   RefSeq; NP_216766.2; NC_000962.3.
DR   RefSeq; WP_003411595.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WMC5; -.
DR   SMR; P9WMC5; -.
DR   STRING; 83332.Rv2250c; -.
DR   PaxDb; P9WMC5; -.
DR   DNASU; 888018; -.
DR   GeneID; 45426230; -.
DR   GeneID; 888018; -.
DR   KEGG; mtu:Rv2250c; -.
DR   TubercuList; Rv2250c; -.
DR   eggNOG; COG1309; Bacteria.
DR   OMA; YRRWPDV; -.
DR   PhylomeDB; P9WMC5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..189
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv2250c"
FT                   /id="PRO_0000070670"
FT   DOMAIN          9..69
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   189 AA;  20494 MW;  C83E52A90C45C214 CRC64;
     MLSMSNDRAD TGGRILRAAA SCVVDYGVDR VTLAEIARRA GVSRPTVYRR WPDTRSIMAS
     MLTSHIADVL REVPLDGDDR EALVKQIVAV ADRLRGDDLI MSVMHSELAR VYITERLGTS
     QQVLIEGLAA RLTVAQRSGS VRSGDARRLA TMVLLIAQST IQSADIVDSI LDSAALATEL
     THALNGYLC