ID   Y2253_MYCBO             Reviewed;         364 AA.
AC   P64956; A0A1R3Y0L4; Q10512; X2BJN1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Uncharacterized protein Mb2253c;
GN   OrderedLocusNames=BQ2027_MB2253C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
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DR   EMBL; LT708304; SIU00861.1; -; Genomic_DNA.
DR   RefSeq; NP_855902.1; NC_002945.3.
DR   RefSeq; WP_003899226.1; NC_002945.4.
DR   AlphaFoldDB; P64956; -.
DR   SMR; P64956; -.
DR   EnsemblBacteria; SIU00861; SIU00861; BQ2027_MB2253C.
DR   GeneID; 45426206; -.
DR   PATRIC; fig|233413.5.peg.2470; -.
DR   OMA; GRWQIKH; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd07067; HP_PGM_like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.40.50.1240; -; 1.
DR   InterPro; IPR013078; His_Pase_superF_clade-1.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR014636; RNaseH/PGlycerate_mutase.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00300; His_Phos_1; 1.
DR   Pfam; PF13456; RVT_3; 1.
DR   PIRSF; PIRSF036922; RNaseH_PGAM; 1.
DR   SMART; SM00855; PGAM; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF53254; SSF53254; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
FT   CHAIN           1..364
FT                   /note="Uncharacterized protein Mb2253c"
FT                   /id="PRO_0000103982"
FT   DOMAIN          1..139
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00408"
SQ   SEQUENCE   364 AA;  39145 MW;  A78E00C9E7D42F9E CRC64;
     MKVVIEADGG SRGNPGPAGY GAVVWTADHS TVLAESKQAI GRATNNVAEY RGLIAGLDDA
     VKLGATEAAV LMDSKLVVEQ MSGRWKVKHP DLLKLYVQAQ ALASQFRRIN YEWVPRARNT
     YADRLANDAM DAAAQSAAAD ADPAKIVATE SPTSPGWTGA RGTPTRLLLL RHGQTELSEQ
     RRYSGRGNPG LNEVGWRQVG AAAGYLARRG GIAAVVSSPL QRAYDTAVTA ARALALDVVV
     DDDLVETDFG AWEGLTFAEA AERDPELHRR WLQDTSITPP GGESFDDVLR RVRRGRDRII
     VGYEGATVLV VSHVTPIKML LRLALDAGSG VLYRLHLDLA SLSIAEFYAD GASSVRLVNQ
     TGYL