ID   Y2265_MYCTU             Reviewed;         409 AA.
AC   P9WLG3; L0TC00; P64961; Q50697;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Uncharacterized protein Rv2265;
GN   OrderedLocusNames=Rv2265; ORFNames=MTCY339.45c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45046.1; -; Genomic_DNA.
DR   PIR; E70729; E70729.
DR   RefSeq; NP_216781.1; NC_000962.3.
DR   RefSeq; WP_003899241.1; NZ_NVQJ01000008.1.
DR   AlphaFoldDB; P9WLG3; -.
DR   SMR; P9WLG3; -.
DR   STRING; 83332.Rv2265; -.
DR   PaxDb; P9WLG3; -.
DR   DNASU; 887976; -.
DR   GeneID; 45426247; -.
DR   GeneID; 887976; -.
DR   KEGG; mtu:Rv2265; -.
DR   PATRIC; fig|83332.111.peg.2520; -.
DR   TubercuList; Rv2265; -.
DR   eggNOG; COG0477; Bacteria.
DR   OMA; FGFHRMM; -.
DR   PhylomeDB; P9WLG3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..409
FT                   /note="Uncharacterized protein Rv2265"
FT                   /id="PRO_0000103991"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   409 AA;  41890 MW;  E07E9B7EF52BC761 CRC64;
     MGANGDVALS RIGATRPALS AWRFVTVFGV VGLLADVVYE GARSITGPLL ASLGATGLVV
     GVVTGVGEAA ALGLRLVSGP LADRSRRFWA WTIAGYTLTV VTVPLLGIAG ALWVACALVI
     AERVGKAVRG PAKDTLLSHA ASVTGRGRGF AVHEALDQVG AMIGPLTVAG MLAITGNAYA
     PALGVLTLPG GAALALLLWL QRRVPRPESY EDCPVVLGNP SAPRPWALPA QFWLYCGFTA
     ITMLGFGTFG LLSFHMVSHG VLAAAMVPVV YAAAMAADAL TALASGFSYD RYGAKTLAVL
     PILSILVVLF AFTDNVTMVV IGTLVWGAAV GIQESTLRGV VADLVASPRR ASAYGVFAAG
     LGAATAGGGA LIGWLYDISI GTLVVVVIAL ELMALVMMFA IRLPRVAPS