ID   Y226_MYCGE              Reviewed;         492 AA.
AC   P47468; Q49367;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2018, sequence version 2.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Uncharacterized protein MG226;
GN   OrderedLocusNames=MG226;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-107.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
RN   [3]
RP   SEQUENCE REVISION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=16407165; DOI=10.1073/pnas.0510013103;
RA   Glass J.I., Assad-Garcia N., Alperovich N., Yooseph S., Lewis M.R.,
RA   Maruf M., Hutchison C.A. III, Smith H.O., Venter J.C.;
RT   "Essential genes of a minimal bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:425-430(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Not essential, it can be deleted.
CC       {ECO:0000269|PubMed:16407165}.
CC   -!- SIMILARITY: To M.genitalium MG225. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD12530.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; L43967; AAC71447.2; -; Genomic_DNA.
DR   EMBL; U02264; AAD12530.1; ALT_INIT; Genomic_DNA.
DR   PIR; I64224; I64224.
DR   RefSeq; WP_010869384.1; NC_000908.2.
DR   AlphaFoldDB; P47468; -.
DR   STRING; 243273.MG_226; -.
DR   TCDB; 2.A.3.6.5; the amino acid-polyamine-organocation (apc) family.
DR   EnsemblBacteria; AAC71447; AAC71447; MG_226.
DR   KEGG; mge:MG_226; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_601059_0_0_14; -.
DR   OrthoDB; 527053at2; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   Pfam; PF00324; AA_permease; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..492
FT                   /note="Uncharacterized protein MG226"
FT                   /id="PRO_0000210469"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   492 AA;  54521 MW;  5E7583473A9E9F57 CRC64;
     MQTNKQPKQQ FSEKQFIAFV FNYIAGFGFI SVVMTMFDVG PFSYLVLGLT SFAILGVVLS
     FSRLSVLCGN SAYGGSYLIA KKAVGTNSKT KRFFVFLSGW NVSLTGSFNG VVIPAVLIFS
     FADIPVVKAN NNIIIGLLVG GFLLFGLLTF ISLFGLKINK KAIFYFAVIK WIVVIGGFIL
     GIYLIGTTNG KGFVENNLIG TRENIDFFKI IFISLALTIA FAGTEDLASI TPDVKSNNLR
     KCFLIAFGCV VLLYLVGFVI ISGLDGIRGY GLALGNKDPK AINNYGSIYR LVGGVPLLVI
     YGLGLLVNSL ASRLSMTITT ARKYVALAQD GFLPSFLAKT NKHNEYHHAV LISNLMTLLV
     MLIMVIIPFL PDHNNNNNSL FNAIEQLVTV TIEMAAAISL IQYFITFIFF FMIFAKKENQ
     KLIPLWEKVS YVISFALVSV LLFVPLFPFN QWTVFNTFKI VVLICFYLLG VGFFGYAEWK
     NKNKYQLMNN NS