ID   Y2277_MYCTU             Reviewed;         301 AA.
AC   P9WLF1; L0T953; Q50687;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Uncharacterized protein Rv2277c;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2277c; ORFNames=MTCY339.33;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
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DR   EMBL; AL123456; CCP45059.1; -; Genomic_DNA.
DR   PIR; A70731; A70731.
DR   RefSeq; NP_216793.1; NC_000962.3.
DR   RefSeq; WP_003916971.1; NZ_NVQJ01000008.1.
DR   PDB; 5VUG; X-ray; 1.50 A; A=24-301.
DR   PDBsum; 5VUG; -.
DR   AlphaFoldDB; P9WLF1; -.
DR   SMR; P9WLF1; -.
DR   STRING; 83332.Rv2277c; -.
DR   PaxDb; P9WLF1; -.
DR   DNASU; 888498; -.
DR   GeneID; 888498; -.
DR   KEGG; mtu:Rv2277c; -.
DR   TubercuList; Rv2277c; -.
DR   eggNOG; COG0584; Bacteria.
DR   OMA; MDCFRSQ; -.
DR   PhylomeDB; P9WLF1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.190; -; 1.
DR   InterPro; IPR030395; GP_PDE_dom.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   Pfam; PF03009; GDPD; 1.
DR   SUPFAM; SSF51695; SSF51695; 1.
DR   PROSITE; PS51704; GP_PDE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..301
FT                   /note="Uncharacterized protein Rv2277c"
FT                   /id="PRO_0000014127"
FT   DOMAIN          31..300
FT                   /note="GP-PDE"
FT   STRAND          32..36
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   TURN            37..42
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           48..56
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          60..68
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          74..76
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          79..81
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           82..84
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           92..94
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           97..100
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   TURN            105..108
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          120..122
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           129..134
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          141..145
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           154..164
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           168..170
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          171..174
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           178..185
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           196..209
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          221..235
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          237..247
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           252..259
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   TURN            260..262
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          265..270
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           274..283
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   STRAND          286..291
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           293..297
FT                   /evidence="ECO:0007829|PDB:5VUG"
FT   HELIX           298..300
FT                   /evidence="ECO:0007829|PDB:5VUG"
SQ   SEQUENCE   301 AA;  32163 MW;  5AD7CE1F28ADE839 CRC64;
     MPGRFTVALV IALGGTCGVA DALPLGQTDD PMIVAHRAGT RDFPENTVLA ITNAVAAGVD
     GMWLTVQVSS DGVPVLYRPS DLATLTDGAG PVNSKTVQQL QQLNAGWNFT TPGVEGHPYR
     QRATPIPTLE QAIGATPPDM TLFLDLKQTP PQPLVSAVAQ VLTRTGAAGR SIVYSTNADI
     TAAASRQEGL QVAESRDVTR QRLFNMALNH HCDPQPDPGK WAGFELHRDV TVTEEFTLGS
     GISAVNAELW DEASVDCFRS QSGMKVMGFA VKTVDDYRLA HKIGLDAVLV DSPLAAQQWR
     H