ID   Y2281_MYCTU             Reviewed;         552 AA.
AC   P9WIA5; L0TAQ9; P65712; Q50684;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Putative phosphate permease Rv2281;
GN   OrderedLocusNames=Rv2281; ORFNames=MTCY339.29c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- FUNCTION: Potential transporter for phosphate. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC       2.A.20) family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45063.1; -; Genomic_DNA.
DR   PIR; E70731; E70731.
DR   RefSeq; NP_216797.1; NC_000962.3.
DR   RefSeq; WP_003411694.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WIA5; -.
DR   SMR; P9WIA5; -.
DR   STRING; 83332.Rv2281; -.
DR   PaxDb; P9WIA5; -.
DR   GeneID; 45426261; -.
DR   GeneID; 887257; -.
DR   KEGG; mtu:Rv2281; -.
DR   PATRIC; fig|83332.111.peg.2536; -.
DR   TubercuList; Rv2281; -.
DR   eggNOG; COG0306; Bacteria.
DR   OMA; MQAFCIA; -.
DR   PhylomeDB; P9WIA5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR001204; Phos_transporter.
DR   PANTHER; PTHR11101; PTHR11101; 1.
DR   Pfam; PF01384; PHO4; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..552
FT                   /note="Putative phosphate permease Rv2281"
FT                   /id="PRO_0000080801"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        493..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   552 AA;  58789 MW;  050847C107DA3716 CRC64;
     MSDNAKHHRD GHLVASGLQD RAARTPQHEG FLGPDRPWHL SFSLLLAGSF VLFSWWAFDY
     AGSGANKVIL VLATVVGMFM AFNVGGNDVA NSFGTSVGAG TLTMKQALLV AAIFEVSGAV
     IAGGDVTETI RSGIVDLSGV SVDPRDFMNI MLSALSAAAL WLLFANRMGY PVSTTHSIIG
     GIVGAAIALG MVSGQGGAAL RMVQWDQIGQ IVVSWVLSPV LGGLVSYLLY GVIKRHILLY
     NEQAERRLTE IKKERIAHRE RHKAAFDRLT EIQQIAYTGA LARDAVAANR KDFDPDELES
     DYYRELHEID AKTSSVDAFR ALQNWVPLVA AAGSMIIVAM LLFKGFKHMH LGLTTMNNYF
     IIAMVGAAVW MATFIFAKTL RGESLSRSTF LMFSWMQVFT ASGFAFSHGS NDIANAIGPF
     AAILDVLRTG AIEGNAAVPA AAMVTFGVAL CAGLWFIGRR VIATVGHNLT TMHPASGFAA
     ELSAAGVVMG ATVLGLPVSS THILIGAVLG VGIVNRSTNW GLMKPIVLAW VITLPSAAIL
     ASVGLVALRA IF