ID   Y2282_MYCTO             Reviewed;         312 AA.
AC   P9WMF2; L0T957; P67667; Q50683;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT2340;
GN   OrderedLocusNames=MT2340;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46624.1; -; Genomic_DNA.
DR   PIR; F70731; F70731.
DR   RefSeq; WP_003411696.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMF2; -.
DR   SMR; P9WMF2; -.
DR   EnsemblBacteria; AAK46624; AAK46624; MT2340.
DR   KEGG; mtc:MT2340; -.
DR   PATRIC; fig|83331.31.peg.2518; -.
DR   HOGENOM; CLU_039613_6_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT2340"
FT                   /id="PRO_0000427314"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  32989 MW;  FFD057C7CA4031F2 CRC64;
     MPLSSRMPGL TCFEIFLAIA EAGSLGGAAR ELGLTQQAVS RRLASMEAQI GVRLAIRTTR
     GSQLTPAGIV VAEWAARLLE VADEIDAGLG SLRTEGRQRI RVVASQTIAE QLMPHWMLSL
     RAADMRRGGT VPEVILTATN SEHAIAAVRD GIADLGFIEN PCPPTGLGSV VVARDELVVV
     VPPGHKWARR SRVVSARELA QTPLVTREPN SGIRDSLTAA LRDTLGEDMQ QAPPVLELSS
     AAAVRAAVLA GAGPAAMSRL AIADDLAFGR LLAVDIPALN LRRQLRAIWV GGRTPPAGAI
     RDLLSHITSR ST