Y2282_MYCTU
ID Y2282_MYCTU Reviewed; 312 AA.
AC P9WMF3; L0T957; P67667; Q50683;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv2282c;
GN OrderedLocusNames=Rv2282c; ORFNames=MTCY339.28;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP45064.1; -; Genomic_DNA.
DR PIR; F70731; F70731.
DR RefSeq; NP_216798.1; NC_000962.3.
DR RefSeq; WP_003411696.1; NZ_NVQJ01000012.1.
DR AlphaFoldDB; P9WMF3; -.
DR SMR; P9WMF3; -.
DR STRING; 83332.Rv2282c; -.
DR PaxDb; P9WMF3; -.
DR DNASU; 887253; -.
DR GeneID; 887253; -.
DR KEGG; mtu:Rv2282c; -.
DR TubercuList; Rv2282c; -.
DR eggNOG; COG0583; Bacteria.
DR OMA; IEGPCHH; -.
DR PhylomeDB; P9WMF3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..312
FT /note="Uncharacterized HTH-type transcriptional regulator
FT Rv2282c"
FT /id="PRO_0000105814"
FT DOMAIN 8..65
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 25..45
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ SEQUENCE 312 AA; 32989 MW; FFD057C7CA4031F2 CRC64;
MPLSSRMPGL TCFEIFLAIA EAGSLGGAAR ELGLTQQAVS RRLASMEAQI GVRLAIRTTR
GSQLTPAGIV VAEWAARLLE VADEIDAGLG SLRTEGRQRI RVVASQTIAE QLMPHWMLSL
RAADMRRGGT VPEVILTATN SEHAIAAVRD GIADLGFIEN PCPPTGLGSV VVARDELVVV
VPPGHKWARR SRVVSARELA QTPLVTREPN SGIRDSLTAA LRDTLGEDMQ QAPPVLELSS
AAAVRAAVLA GAGPAAMSRL AIADDLAFGR LLAVDIPALN LRRQLRAIWV GGRTPPAGAI
RDLLSHITSR ST