ID   Y2282_MYCTU             Reviewed;         312 AA.
AC   P9WMF3; L0T957; P67667; Q50683;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv2282c;
GN   OrderedLocusNames=Rv2282c; ORFNames=MTCY339.28;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45064.1; -; Genomic_DNA.
DR   PIR; F70731; F70731.
DR   RefSeq; NP_216798.1; NC_000962.3.
DR   RefSeq; WP_003411696.1; NZ_NVQJ01000012.1.
DR   AlphaFoldDB; P9WMF3; -.
DR   SMR; P9WMF3; -.
DR   STRING; 83332.Rv2282c; -.
DR   PaxDb; P9WMF3; -.
DR   DNASU; 887253; -.
DR   GeneID; 887253; -.
DR   KEGG; mtu:Rv2282c; -.
DR   TubercuList; Rv2282c; -.
DR   eggNOG; COG0583; Bacteria.
DR   OMA; IEGPCHH; -.
DR   PhylomeDB; P9WMF3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv2282c"
FT                   /id="PRO_0000105814"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..45
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  32989 MW;  FFD057C7CA4031F2 CRC64;
     MPLSSRMPGL TCFEIFLAIA EAGSLGGAAR ELGLTQQAVS RRLASMEAQI GVRLAIRTTR
     GSQLTPAGIV VAEWAARLLE VADEIDAGLG SLRTEGRQRI RVVASQTIAE QLMPHWMLSL
     RAADMRRGGT VPEVILTATN SEHAIAAVRD GIADLGFIEN PCPPTGLGSV VVARDELVVV
     VPPGHKWARR SRVVSARELA QTPLVTREPN SGIRDSLTAA LRDTLGEDMQ QAPPVLELSS
     AAAVRAAVLA GAGPAAMSRL AIADDLAFGR LLAVDIPALN LRRQLRAIWV GGRTPPAGAI
     RDLLSHITSR ST