ID   Y2287_MYCTO             Reviewed;         542 AA.
AC   P9WJI2; L0T963; P65526; Q50678;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized Na(+)/H(+) exchanger MT2345;
GN   OrderedLocusNames=MT2345;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK46629.1; -; Genomic_DNA.
DR   PIR; C70732; C70732.
DR   RefSeq; WP_003411714.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJI2; -.
DR   SMR; P9WJI2; -.
DR   EnsemblBacteria; AAK46629; AAK46629; MT2345.
DR   KEGG; mtc:MT2345; -.
DR   PATRIC; fig|83331.31.peg.2524; -.
DR   HOGENOM; CLU_005912_8_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015299; F:solute:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..542
FT                   /note="Uncharacterized Na(+)/H(+) exchanger MT2345"
FT                   /id="PRO_0000427825"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   542 AA;  57491 MW;  F73AA73A4068DCBC CRC64;
     MNGRRTIGED GLVFGLVVIV ALVAAVVVGT VLGHRYRVGP PVLLILSGSL LGLIPRFGDV
     QIDGEVVLLL FLPAILYWES MNTSFREIRW NLRVIVMFSI GLVIATAVAV SWTARALGME
     SHAAAVLGAV LSPTDAAAVA GLAKRLPRRA LTVLRGESLI NDGTALVLFA VTVAVAEGAA
     GIGPAALVGR FVVSYLGGIM AGLLVGGLVT LLRRRIDAPL EEGALSLLTP FAAFLLAQSL
     KCSGVVAVLV SALVLTYVGP TVIRARSRLQ AHAFWDIATF LINGSLWVFV GVQIPGAIDH
     IAGEDGGLPR ATVLALAVTG VVIATRIAWV QATTVLGHTV DRVLKKPTRH VGFRQRCVTS
     WAGFRGAVSL AAALAVPMTT NSGAPFPDRN LIIFVVSVVI LVTVLVQGTS LPTVVRWARM
     PEDVAHANEL QLARTRSAQA ALDALPTVAD ELGVAPDLVK HLEKEYEERA VLVMADGADS
     ATSDLAERND LVRRVRLGVL QHQRQAVTTL RNQNLIDDIV LRELQAAMDL EEVQLLDPAD
     AE