Y2287_MYCTU
ID Y2287_MYCTU Reviewed; 542 AA.
AC P9WJI3; L0T963; P65526; Q50678;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Uncharacterized Na(+)/H(+) exchanger Rv2287;
GN OrderedLocusNames=Rv2287; ORFNames=MTCY339.23c;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; AL123456; CCP45069.1; -; Genomic_DNA.
DR PIR; C70732; C70732.
DR RefSeq; NP_216803.1; NC_000962.3.
DR RefSeq; WP_003411714.1; NC_000962.3.
DR AlphaFoldDB; P9WJI3; -.
DR SMR; P9WJI3; -.
DR STRING; 83332.Rv2287; -.
DR PaxDb; P9WJI3; -.
DR GeneID; 887570; -.
DR KEGG; mtu:Rv2287; -.
DR PATRIC; fig|83332.111.peg.2542; -.
DR TubercuList; Rv2287; -.
DR eggNOG; COG0025; Bacteria.
DR OMA; AGMMMNY; -.
DR PhylomeDB; P9WJI3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR TIGRFAMs; TIGR00831; a_cpa1; 1.
PE 1: Evidence at protein level;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..542
FT /note="Uncharacterized Na(+)/H(+) exchanger Rv2287"
FT /id="PRO_0000052400"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 542 AA; 57491 MW; F73AA73A4068DCBC CRC64;
MNGRRTIGED GLVFGLVVIV ALVAAVVVGT VLGHRYRVGP PVLLILSGSL LGLIPRFGDV
QIDGEVVLLL FLPAILYWES MNTSFREIRW NLRVIVMFSI GLVIATAVAV SWTARALGME
SHAAAVLGAV LSPTDAAAVA GLAKRLPRRA LTVLRGESLI NDGTALVLFA VTVAVAEGAA
GIGPAALVGR FVVSYLGGIM AGLLVGGLVT LLRRRIDAPL EEGALSLLTP FAAFLLAQSL
KCSGVVAVLV SALVLTYVGP TVIRARSRLQ AHAFWDIATF LINGSLWVFV GVQIPGAIDH
IAGEDGGLPR ATVLALAVTG VVIATRIAWV QATTVLGHTV DRVLKKPTRH VGFRQRCVTS
WAGFRGAVSL AAALAVPMTT NSGAPFPDRN LIIFVVSVVI LVTVLVQGTS LPTVVRWARM
PEDVAHANEL QLARTRSAQA ALDALPTVAD ELGVAPDLVK HLEKEYEERA VLVMADGADS
ATSDLAERND LVRRVRLGVL QHQRQAVTTL RNQNLIDDIV LRELQAAMDL EEVQLLDPAD
AE
