ID   Y2288_MYCMM             Reviewed;         335 AA.
AC   B2HPD3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=UPF0353 protein MMAR_2288 {ECO:0000255|HAMAP-Rule:MF_01340};
GN   OrderedLocusNames=MMAR_2288;
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01340};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01340}.
CC   -!- SIMILARITY: Belongs to the UPF0353 family. {ECO:0000255|HAMAP-
CC       Rule:MF_01340}.
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DR   EMBL; CP000854; ACC40737.1; -; Genomic_DNA.
DR   RefSeq; WP_012394040.1; NC_010612.1.
DR   AlphaFoldDB; B2HPD3; -.
DR   SMR; B2HPD3; -.
DR   STRING; 216594.MMAR_2288; -.
DR   EnsemblBacteria; ACC40737; ACC40737; MMAR_2288.
DR   KEGG; mmi:MMAR_2288; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_024570_2_0_11; -.
DR   OMA; RYFRATD; -.
DR   OrthoDB; 736429at2; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.410; -; 1.
DR   HAMAP; MF_01340; UPF0353; 1.
DR   InterPro; IPR022933; UPF0353.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="UPF0353 protein MMAR_2288"
FT                   /id="PRO_1000142755"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
FT   DOMAIN          98..294
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01340"
SQ   SEQUENCE   335 AA;  35923 MW;  9AD5DEFAB5D92E92 CRC64;
     MTLPLLGPMT LSGFAHSWFF LFIFVIAGLI AVYVVLQLAR QKRMLRFANM ELLESVAPQR
     PSRFRHIPAM LLALSLVLFT VAMAGPTHDV RIPRNRAVVM LVIDVSQSMR ATDVEPNRMV
     AAQEAAKQFA DELTPGINLG LIAYAGTATV LVSPTTNREA TKAALDKLQF ADRTATGEAI
     FTALQAIATV GAVIGGGDTP PPARIVLFSD GKETMPTNPD NPKGAYTAAR TAKDQGVPIS
     TISFGTPYGF VEINDQRQPV PVDDETMKKV AQLSGGNSYN AATLAELNSV YASLQQQIGY
     ETIRGDASMG WLRLGALVLV AAALAALLIN RRLPT