ID   Y2293_MYCTU             Reviewed;         246 AA.
AC   P9WLE1; L0T9E0; Q50673;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized protein Rv2293c;
DE   Flags: Precursor;
GN   OrderedLocusNames=Rv2293c; ORFNames=MTCY339.17;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00303}; Multi-pass membrane protein {ECO:0000305}.
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DR   EMBL; AL123456; CCP45075.1; -; Genomic_DNA.
DR   PIR; A70733; A70733.
DR   RefSeq; NP_216809.1; NC_000962.3.
DR   RefSeq; WP_003899254.1; NC_000962.3.
DR   AlphaFoldDB; P9WLE1; -.
DR   SMR; P9WLE1; -.
DR   STRING; 83332.Rv2293c; -.
DR   PaxDb; P9WLE1; -.
DR   DNASU; 887283; -.
DR   GeneID; 887283; -.
DR   KEGG; mtu:Rv2293c; -.
DR   TubercuList; Rv2293c; -.
DR   eggNOG; COG0775; Bacteria.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1580; -; 1.
DR   InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR   InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR   Pfam; PF01048; PNP_UDP_1; 1.
DR   SUPFAM; SSF53167; SSF53167; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           25..246
FT                   /note="Uncharacterized protein Rv2293c"
FT                   /id="PRO_0000014130"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   246 AA;  25255 MW;  35710591F556A4A0 CRC64;
     MGAPLRHCLL VAAALSLGCG VAAADPGYVA NVIPCEQRTL VLSAFPAEAD AVLAHTALDA
     NPVVVADRRR YYLGSISGKK VIVAMTGIGL VNATNTTETA FARFTCASSI AIAAVMFSGV
     AGGAGRTSIG DVAIPARWTL DNGATFRGVD PGMLATAQTL SVVLDNINTL GNPVCLCRNV
     PVVRLNHLGR QPQLFVGGDG SSSDKNNGQA FPCIPNGGSV FAANPVVHPI AHLAIPVTFS
     RRRDPG