ID   Y2295_MYCTU             Reviewed;         187 AA.
AC   P9WFL7; L0TBV7; P67309; Q50671;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=UPF0167 protein Rv2295;
GN   OrderedLocusNames=Rv2295; ORFNames=MTCY339.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Beijing GC1237;
RX   PubMed=20844580; DOI=10.1371/journal.ppat.1001100;
RA   Brodin P., Poquet Y., Levillain F., Peguillet I., Larrouy-Maumus G.,
RA   Gilleron M., Ewann F., Christophe T., Fenistein D., Jang J., Jang M.S.,
RA   Park S.J., Rauzier J., Carralot J.P., Shrimpton R., Genovesio A.,
RA   Gonzalo-Asensio J.A., Puzo G., Martin C., Brosch R., Stewart G.R.,
RA   Gicquel B., Neyrolles O.;
RT   "High content phenotypic cell-based visual screen identifies Mycobacterium
RT   tuberculosis acyltrehalose-containing glycolipids involved in phagosome
RT   remodeling.";
RL   PLoS Pathog. 6:E1001100-E1001100(2010).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Probably plays a role in host phagosome maturation arrest
CC       (PubMed:20844580). {ECO:0000305|PubMed:20844580}.
CC   -!- DISRUPTION PHENOTYPE: Grows normally in liquid culture, traffics into
CC       host (human and mouse) acidified compartments early after phagocytosis,
CC       suggesting it no longer arrests phagosome maturation as well as wild-
CC       type, impaired growth in mouse macrophages (PubMed:20844580).
CC       {ECO:0000269|PubMed:20844580}.
CC   -!- SIMILARITY: Belongs to the UPF0167 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP45077.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP45077.1; ALT_INIT; Genomic_DNA.
DR   PIR; C70733; C70733.
DR   RefSeq; NP_216811.1; NC_000962.3.
DR   AlphaFoldDB; P9WFL7; -.
DR   STRING; 83332.Rv2295; -.
DR   PaxDb; P9WFL7; -.
DR   DNASU; 888540; -.
DR   GeneID; 888540; -.
DR   KEGG; mtu:Rv2295; -.
DR   TubercuList; Rv2295; -.
DR   eggNOG; COG3196; Bacteria.
DR   OMA; YLCPWCI; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0052170; P:suppression by symbiont of host innate immune response; IDA:MTBBASE.
DR   InterPro; IPR005363; UPF0167.
DR   Pfam; PF03691; UPF0167; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..187
FT                   /note="UPF0167 protein Rv2295"
FT                   /id="PRO_0000209366"
SQ   SEQUENCE   187 AA;  20691 MW;  253AB68AD21DE9FB CRC64;
     MPVEETSTPQ KLPQFRYHPD PVGTGSIVAD EVSCVSCEQR RPYTYTGPVY AEEELNEAIC
     PWCIADGSAA SRFDATFTDA MWAVPDDVPE DVTEEVLCRT PGFTGWLQEE WLHHCGDAAA
     FLGPVGASEV ADLPDALDAL RNEYRGYDWP ADKIEEFILT LDRNGLATAY LFRCLSCGVH
     LAYADFA